| 摘要: |
| 目的 评估血府逐瘀汤在泡沫硬化剂联合大隐静脉(GSV)高位结扎和腔内激光闭合术(EVLT)治疗下肢静脉曲张的效果，分析循环内皮细胞 (CEC)、内皮素 -1(ET-1)和一氧化氮 (NO)水平变化。方法:回顾性纳入我院于 2020年 10月— 2022年 10月收治的 368例下肢静脉曲张患者，根据疗法分为对照组和研究组两组，每组各 184例。对照组接受泡沫硬化剂联合 GSV高位结扎及 EVLT治疗，研究组在对照组基础上加用血府逐瘀汤。均连续治疗 8周。比较两组临床症状消失时间、 CEC、ET-1、 NO、血液流变学指标、炎症因子及 GSV治疗长度、GSV闭合率、住院时间，以及血清 B淋巴细胞瘤 -2(Bcl-2)、B淋巴细胞瘤因子相关 X蛋白(Bax)和半胱氨酸天冬氨基酸蛋白酶 -3(Caspase-3)水平的差异。结果:研究组患者下肢症状消失时间显著短于对照组。治疗后，两组血管内皮功能和血液流变学指标均改善，研究组改善更显著(p<0.05)。研究组住院时间短于对照组(p<0.05)。治疗后，研究组 Bcl-2、Caspase-3水平显著高于对照组，而 Bax水平低于对照组(p<0.05)。结论:血府逐瘀汤联合泡沫硬化剂、GSV高位结扎和 EVLT治疗下肢静脉曲张可加速临床症状缓解，改善血管内皮功能及血液流变学指标，抑制炎症反应，具有良好的临床效果 |
| 关键词: 血府逐瘀汤 泡沫硬化剂 大隐静脉高位结扎 腔内激光闭合术 下肢静脉曲张 |
| DOI：10.3969/j.issn.1007-6948.2025.01.017 |
| 投稿时间：2024-04-21 |
| 基金项目: |
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| Effect of Xuefu Zhuyu decoction combined with foam sclerotherapy combined with high ligation of great saphenous vein and EVLT on CEC, ET-1 and NO in patients with lower extremity varicose veins |
| JINLi-qiang,GUO Hai-tao,HAN Shu-ming |
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| Abstract: |
| Objective To evaluate the effect of Xuefu Zhuyu decoction in the treatment of varicose veins of lower extremities with foam sclerotherapy combined with high ligation of saphenous vein and intracavitary laser closure (EVLT), and analyze the changes of CEC, ET-1 and NO levels. Methods 368 patients with lower limb varicose veins admitted to our hospital from October 2020 to October 2022 were retrospectively included, and were divided into control group and study group according to treatment, with 184 cases each. The control group was treated with foam sclerotherapy combined with high ligation of great saphenous vein and EVLT, while the study group was treated with Xuefu Zhuyu decoction combined with foam sclerotherapy, high ligation of great saphenous vein and EVLT. Continuous treatment for 8 weeks. The time of clinical symptom resolution, CEC, ET-1, NO, hemorheology indexes, inflammatory factors, length of great saphenous vein treatment, GSV closure rate,length of hospital stay and serum Bcl-2, Bax, Caspase-3 levels were compared between the two groups. Results The disappearance time of lower limb symptoms in the study group was significantly shorter than that in the control group. After treatment, vascular endothelial function and hemorheology indexes were improved in both groups, and the improvement was more significant in the study group (p<0.05). The hospital stay of the study group was shorter than that of the control group (p<0.05). After treatment, the levels of Bcl-2 and Caspase-3 in the study group were significantly higher than those in the control group, while the levels of Bax were lower than those in the control group (p<0.05).Conclusion Xuefu Zhuyu decoction combined with foamsclerotherapy, saphenous vein high ligation and EVLT in the treatment of varicose veins of lower limbs can accelerate the remission of clinical symptoms, improve vascular endothelial function and hemorheology indexes, inhibit inflammation, and have good clinical effects. |
| Key words: Xuefu Zhuyu decoction foam hardener high ligation of great saphenous vein intracavitary laser closure lower limb varicose veins |
