| 摘要: |
| 目的:通过Meta分析研究肝切除术对于T2期胆囊癌患者预后的影响。方法:检索Pubmed、Embase、Web of Science、Cochrane Library、中国知网、万方、维普网站。英文检索词汇包括:gallbladder carcinoma, surgery, cholecystectomy, radical cholecystectomy, hepatectomy, liver resection。中文检索词汇包括:胆囊癌、手术、胆囊切除术、根治性胆囊切除、肝切除。比较两组患者的总体生存率、无病生存率、术后并发症和术后30 d死亡率。使用RevMan 5.4统计软件对数据进行Meta分析。结果:共有20个研究包含3222例患者被纳入，其中1959例患者进行了肝切除，1263例未进行肝切除。Meta分析结果显示，肝切除组与非肝切除组患者术后总生存率[风险比(RR)＝0.93，95%CI:0.77~1.12，P =0.44]，术后无病生存率(RR＝1.11，95%CI:0.84~1.47，P =0.45)，术后并发症发生率(RR＝2.00，95%CI:0.71~5.62，P =0.19)及术后30 d内死亡率(RR＝0.90，95%CI:0.10~8.02，P =0.92)均无显著统计学差异。结论:对于T2期胆囊癌的患者，并不能从肝切除术中获益。 |
| 关键词: 胆囊癌 胆囊切除 肝切除 |
| DOI：10.3969/j.issn.1007-6948.2024.06.022 |
| 投稿时间：2024-04-09 |
| 基金项目:天津市卫健委中西医结合课题(2023095) |
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| Meta-analysis on the necessity of hepatectomy for T2 stage gallbladder cancer |
| SUN Zhe,XU Xin-sheng,ZHAO Hong-zhi |
| Tianjin Hospital of Integrated Traditional Chinese and Western Medicine , Tianjin300100, China |
| Abstract: |
| Objective To investigate the impact of hepatectomy on the prognosis of patients with T2 stage gallbladder cancer through Meta-analysis. Methods Databases including PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, and VIP Database were searched. The search terms included: gallbladder carcinoma, surgery, cholecystectomy, radical cholecystectomy, hepatectomy, liver resection. Comparative analysis was conducted on indicators such as overall survival, disease-free survival, postoperative complication rate, and mortality within 30 days after surgery between the hepatectomy group and the non-hepatectomy group. Meta-analysis was performed using RevMan 5.4 software. Results A total of 20 studies involving 3222 patients were included, with 1959 patients in the hepatectomy group and 1263 patients in the non-hepatectomy group. Meta-analysis results showed no significant statistical differences in postoperative overall survival rate (RR=0.93, 95%CI: 0.77-1.12, P =0.44), postoperative disease-free survival rate (RR=1.11, 95%CI: 0.84-1.47, P =0.45), postoperative complication rate (RR=2.00，95%CI:0.71-5.62，P =0.19, and mortality within 30 days after surgery (RR=0.90, 95%CI: 0.10-8.02, P =0.92) between the hepatectomy group and the non-hepatectomy group. Conclusion Hepatectomy does not benefit patients with T2 stage gallbladder cancer. |
| Key words: Gall bladder cancer cholecystectomy hepatectomy |
