| 摘要: |
| 目的 探讨血清胰岛素样生长因子-1(IGF-1)、肝细胞生长因子(HGF)、肿瘤间质比值(TSR)诊断乳腺癌发生淋巴结转移的价值及与患者预后的关系。方法:采取回顾性研究方法，选取2015年6月—2017年8月北京市通州区妇幼保健院乳腺科收治的120例乳腺癌患者作为研究对象，根据手术后病理学结果患者是否发生淋巴结转移将其分为复发转移组24例、未复发转移组96例，对比两组患者的血清IGF-1、HGF、TSR值，采用受试者工作曲线分析三项指标诊断乳腺癌患者发生淋巴结转移的价值；采用Logistic回归模型分析乳腺癌病理学特征、治疗方法及IGF-1、HGF、TSR与乳腺癌患者预后结局的关系。结果:乳腺癌淋巴结转移组患者的IGF-1、HGF测定值高于非转移组，TSR水平低于非转移组，差异均有统计学意义(P<0.05)；IGF-1、HGF、TSR测定值诊断乳腺癌发生淋巴结转移的ROC曲线下面积值分别为0.837(0.766～0.907)、0.842(0.773～0.911)、0.880(0.821～0.938)；Logistic回归分析结果显示:TNM分期≥Ⅱ期、发生淋巴结转移、IGF-1水平增高、HGF水平增高、TSR低水平会增大乳腺癌患者手术治疗后复发转移的风险(P<0.05)。结论:IGF-1、HGF水平增高及TSR降低会增大乳腺癌患者发生手术后复发的风险，术前检查IGF-1、HGF及TSR可以评估是否发生淋巴结转移，对手术方案制定有一定的参考价值。 |
| 关键词: 胰岛素样生长因子-1 肝细胞生长因子 肿瘤间质比值 乳腺癌 淋巴结转移 预后 |
| DOI：10.3969/j.issn.1007-6948.2023.05.014 |
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| 基金项目:北京市通州区科技计划项目(KJ2022CX060) |
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| Evaluation of lymph node metastasis and its relationship with prognosis in breast cancer patients by combined detection of serum insulin-like growth factor-1, hepatocyte growth factor and tumor stroma ratio |
| LIANG Qiu,JIAO Ming-yuan,LI Zhi |
| Breast Department of Beijing Tongzhou District Maternal and Child Health Hospital, Beijing101101, China |
| Abstract: |
| Objective To investigate the value of serum insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF) and tumor stroma ratio (TSR) in the diagnosis of lymph node metastasis in breast cancer and their relationship with prognosis. Methods A retrospective study was conducted to select 120 patients with breast cancer who were admitted to the Breast Department of Tongzhou District Maternal and Child Health Hospital from June 2015 to August 2017 as the study subjects. According to the pathological results after surgery, the patients were divided into 24 patients with recurrent metastasis and 96 patients without recurrent metastasis, and the serum IGF-1, HGF, TSR values of the two groups were compared, The value of three indicators in the diagnosis of lymph node metastasis in breast cancer patients was analyzed by subject work curve; Logistic regression model was used to analyze the relationship between the pathological characteristics, treatment methods, IGF-1, HGF, TSR and the prognosis of breast cancer patients. Results IGF-1 and HGF in patients with lymph node metastasis of breast cancer were significantly higher than those in patients without metastasis, and TSR in patients with breast cancer metastasis was significantly lower than those in patients without metastasis (P<0.05); The AUC values under the ROC curve of IGF-1, HGF and TSR for diagnosis of lymph node metastasis in breast cancer were 0.837 (0.766-0.907), 0.842 (0.773-0.911) and 0.880 (0.821-0.938), respectively; Logistic regression model: TNM stage ≥ stage II, lymph node metastasis, elevated IGF-1 level, elevated HGF level, and low TSR level will increase the risk of recurrence and metastasis of breast cancer patients after surgery (P<0.05). Conclusion The increase of IGF-1, HGF and TSR levels and the decrease of TSR will increase the risk of postoperative recurrence in breast cancer patients. Preoperative examination of IGF-1, HGF and TSR can evaluate whether lymph node metastasis occurs, which has certain reference value for the formulation of surgical plan. |
| Key words: Insulin like growth factor-1 hepatocyte growth factor tumor stroma ratio breast cancer lymph node metastasis prognosis |
