| 摘要: |
| 目的:分析中药和胃化湿方对胃肠道肿瘤术后肠道功能的改善作用。方法:随机抽取2019 年1 月—2020 年1 月间在本院接受诊疗的94 例胃肠道肿瘤手术患者，根据随机数字表法将其分为两组，对照47 例术后予以常规西医治疗，观察组47 例术后予以和胃化湿方治疗，2 周后对比两组中医证候疗效、胃肠功能恢复情况、胃肠道黏膜屏障及肠道微生态水平。结果:观察组治疗后中医证候总有效率为95.74%，高于对照组的78.72%，差异有统计学意义(P ＜ 0.05)；观察组术后首次排气、全流恢复、首次排便、腹胀消失及肠鸣音恢复的时间均比对照组短，差异有统计学意义(P ＜ 0.05)；观察组治疗后的肠脂肪酸结合蛋白(I-FABP)为(53.53±5.96)μg/L，D- 乳酸水平为(2.50±0.61)mmol/L，分别比对照组的(58.96±5.11)μg/L 及(3.15±0.78)mmol/L 低，差异有统计学意义(P ＜ 0.05)；观察组治疗后的肠道乳杆菌数量为(8.83±1.01) lgCFU/mL，双歧杆菌数量为(9.15±0.86) lgCFU/mL，分别比对照组的(7.90±1.12) lgCFU/mL 及(8.66±1.05)lgCFU/mL 多，而观察组的肠球菌数量为(6.25±0.92)lgCFU/mL，比对照组的(6.68±0.99) lgCFU/mL 少，差异有统计学意义(P ＜ 0.05)。结论:和胃化湿方治疗胃肠道肿瘤患者术后的效果显著，有助于改善患者胃肠功能，促进胃肠功能恢复，并改善胃肠道黏膜屏障及肠道微生态水平。 |
| 关键词: 胃肠道肿瘤 和胃化湿方 胃肠功能 肠道微生态 胃肠道黏膜屏障 |
| DOI：10.3969/j.issn.1007-6948.2021.06.012 |
| 投稿时间：2021-01-09 |
| 基金项目: |
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| Effect of Hewei Huashi Recipe on Intestinal Function after Gastrointestinal Tumor Surgery |
| HAN Chun-qi,YANG Lian-ying |
| First Surgery Department, Tianjin Baodi District People' s Hospital, Tianjin 301800, China |
| Abstract: |
| Objective To analyze the effect of traditional Chinese medicine Hewei Huashi Recipe on improving intestinal function after gastrointestinal tumor surgery. Methods 94 cases of patients who were undergoing gastrointestinal tumor surgery in our hospital from January 2019 to January 2020 were randomly collected and divided into two groups according to the random number table method. 47 cases in the control group were treated with conventional western medicine after operation, while other 47 cases in the observation group were treated with Hewei Huashi Decoction after operation. The efficacy of TCM syndromes, gastrointestinal function recovery, gastrointestinal mucosal barrier and intestinal microecological level were compared between the two groups after two weeks. Results In the observation group, the total effective rate of TCM syndromes after treatment was 95.74%, which was higher than 78.72% in the control group (P <0.05). In the observation group, the postoperative first exhaust time, full flow recovery time, first defecation time, abdominal distension disappearance time and bowel sound recovery time were shorter than those of the control group (P <0.05). In the observation group, the I-FABP after treatment was (53.53±5.96) μg/L, and the D-lactic acid level was (2.50±0.61) mmol/L, which were higher than the (58.96±5.11) μg/L and (3.15±0.78 ) mmol/L of the control group respectively (P <0.05). In the observation group, the number of intestinal lactobacilli after treatment was (8.83±1.01) lgCFU/ml, and the number of bifidobacteria was (9.15±0.86) lgCFU/ml, which were respectively more than those in the control group (7.90±1.12) lgCFU/ml and (8.66±1.05) lgCFU/ml, while the number of enterococci in the observation group was (6.25±0.92) lgCFU/ml, which was less than (6.68±0.99) lgCFU/ml of the control group (P <0.05). Conclusion Postoperative treatment of gastrointestinal cancer patients with Hewei Huashi Decoction has a significant effect, which could help to improve the gastrointestinal function of the patient, promote the recovery of gastrointestinal function as well as improve the gastrointestinal mucosal barrier and intestinal microecological level. |
| Key words: Gastrointestinal tumors Hewei Huashi recipe gastrointestinal function intestinal microecology gastrointestinal mucosal barrier |
