| 摘要: |
| 目的:探讨温脾化瘀汤联合吉西他滨治疗胰腺癌患者的效果及对卡氏评分、癌胚抗原的影响。方法:选取2019年6月—2020年6月本院收治的50例胰腺癌患者，按随机数字表分为两组，对照组(25例)患者给予单纯吉西他滨治疗，观察组(25例)患者给予吉西他滨+温脾化瘀汤治疗，观察两组患者的中医症候积分、卡氏评分、癌胚抗原、糖类抗原199(CA199)、生活质量、总疗效、不良反应情况及生存情况等。结果:治疗后，观察组中医症候积分、卡氏评分高于对照组，癌胚抗原低于对照组，差异有统计学意义(P<0.05)；观察组CA199水平与对照组差异无统计学意义(P>0.05)；两组患者生活质量核心调查量表(QLQC-30)各项评分及总评分均得到明显改善，且观察组改善效果显著高于对照组，差异有统计学意义(P<0.05)；观察组治疗总有效率为92%，高于对照组的68%，不良反应总发生率为12%，低于对照组的36%，差异有统计学意义(P<0.05)。结论:选用温脾化瘀汤、吉西他滨联合方案治疗胰腺癌，可明显提高患者的卡氏评分，降低癌胚抗原，提高生活质量，且减少药物不良反应。 |
| 关键词: 胰腺癌 吉西他滨 温脾化瘀汤 卡氏评分 癌胚抗原 |
| DOI：10.3969/j.issn.1007-6948.2021.04.003 |
| 投稿时间：2020-12-05 |
| 基金项目: |
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| Effect of Wenpi Huayu Decoction Combined with Gissi on Pancreatic Cancer Patients and Its Influence on KCS Score and CEA |
| HU Yong-jin,DU Xue-ming,WU Chun-wa |
| Department of Oncology, Tianjin Beichen Hospital, Tianjin300400, China |
| Abstract: |
| Objective To investigate the effect of Wenpi Huayu decoction (WPT) and Gissi Tabin (Tabin) in the treatment of patients with pancreatic cancer. Methods 50 patients with pancreatic cancer admitted to our hospital from June 2019 to June 2020 were randomly divided into two groups. The patients in the control group (25 cases) were treated with Gissi alone, the patients in the Observation Group (25 cases) were treated with Gissi and Wenpi Huayu decoction. The TCM symptom score, Karnofsky score, CEA, CA199, quality of life, total effect, adverse reaction and survival were observed. Results After treatment, the score of TCM symptom, Kardashian score and CEA in the observation group were significantly higher than those in the control group (P<0.05), and the level of CA199 index in the observation group was not significantly different from that in the control group (P>0.05). All scores and total scores of QLQC-30 were significantly improved in the two groups, and the improvement effect of the observation group was significantly higher than that of the control group (P<0.05). The total effective rate of the two groups was 68% and 92% respectively, which the observation group was significantly higher.The total incidence of adverse reactions were36% and 12%, which the observation group was significantly lower (P <0.05). Conclusion The combination of Wenpi Huayu decoction and Gissi Tabin can significantly improve the effect of Karnofsky score, reduce the CEA in patients with pancreatic cancer, enhance thequality of life after treatment, achieve better therapeutic effectiveness and reduce adverse drug reactions. |
| Key words: Pancreatic cancer gissi taibin warming spleen and removing blood stasis decoction Cartesian score carcinoembryonic antigen |
