| 摘要: |
| 目的:观察以柴芍解郁汤为基础方，不同剂量柴胡白芍药对作用于大肠癌术后患者的疗效。方法:将108例大肠癌术后患者随机分为四组:柴胡白芍药对低、中、高剂量组以及对照组(每组27例)，对照组患者接受蒙脱石散口服，低、中、高剂量组在柴芍解郁汤基础上分别给予不同比例柴胡白芍配伍(6 g:10 g；10 g:15 g；15 g:20 g)，比较各组患者治疗前后血清5-羟色胺(5-HT)、多巴胺(DA)、汉密尔顿抑郁量表(HAMD)水平，及腹泻症状改善情况。结果:低、中、高剂量组治疗后患者5-HT、DA水平明显高于治疗前(t 5-HT =8.856,9.218,11.265，P<0.05；tDA=7.138,9.281,13.312，P<0.05)，中高剂量组治疗后患者HAMD评分明显低于治疗前水平(t =5.218,13.256；P<0.05)，高剂量组治疗后患者腹泻改善情况明显优于对照组(χ2 =18.79，P<0.05)。结论:大肠癌术后患者抑郁状态及腹泻症状改善情况随柴芍剂量升高而相应提升，该药对剂量变化对患者治疗效果起着重要作用。 |
| 关键词: 柴胡白芍药对 大肠癌 抑郁 腹泻 量效关系 |
| DOI：10.3969/j.issn.1007-6948.2021.03.016 |
| 投稿时间：2020-10-08 |
| 基金项目:国家自然科学基金青年基金项目(81803711) |
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| Study on the Dose-Effect Relationship of the Radix Bupleuri and Radix Paeoniae Alba Drug Pair on Improving Depression and Diarrhea of Patients with Colorectal Cancer Operation |
| HU Ming-xu,XU Qiaoqiao,ZHANG Hong-cai |
| Department of Oncology, Heilongjiang Hospital of Chinese Medicine, Harbin (150001), China |
| Abstract: |
| Objective To observe the efficacy of different doses of the radix bupleuri and radix paeoniae alba drug pair on patients with colorectal cancer surgery. Methods Postoperative patients with colorectal cancer were randomly divided into four groups: low-medium and high-dose drug pair groups and control group (CP)，which 27 patients per group, Patients in the CP received montmorillonite powder orally. The low-medium-highdose group were given different proportions of bupleuri and paeoniae alba compatibility (6 g: 10 g; 10 g: 15 g; 15 g: 20 g) based on Chaishao Jieyu Decoction. The levels of serum serotonin (5-HT), dopamine (DA), Hamilton Depression Scale (HAMD) and diarrhea symptoms were compared before and after treatment. Results The 5-HT and DA levels in patients after treatment in the low-medium-high-dose group are higher than those of the pre-treatment level (t 5-HT =8.856, 9.218, 11.265. P<0.05; tDA =7.138, 9.281, 13.312. P<0.05). After treatment, the HAMD scores of the patients in the high-dose group was significantly lower than that in the pre-treatment (t=5.218, 13.256; P<0.05) and the improvement of diarrhea in the high-dose group was higher than that in the CP (χ2 =18.79, P<0.05). Conclusion The improvement of depression and diarrhea symptoms of postoperative patients with colorectal cancer increased with the increase of the dose of bupleuri and paeoniae alba. The dose changing of the drug pair played an important role in the treatment effect of patients. |
| Key words: Radix bupleuri and radix paeoniae alba drug pair colorectal cancer depression diarrhea dose-effect relationship |
