| 摘要: |
| 目的:探讨前列舒通胶囊联合盐酸坦索罗辛胶囊治疗经尿道前列腺切除术(TURP)后前列腺炎患者治疗的临床效果及对炎性因子水平的影响。方法:选取本院在2018年5月—2019年10月收治的60例TURP术后前列腺炎患者作为对象，采用随机数字表法分为两组。对照组给予盐酸坦索罗辛胶囊治疗，观察组给予盐酸坦索罗辛胶囊+前列舒通胶囊治疗。观察患者症状、炎症反应改善、总疗效及不良反应发生情况。结果:观察组治疗后NIH-CPSI评分中排尿症状、疼痛、生活质量评分及总分均低于对照组，差异有统计学意义(t=4.518、10.527、14.889、12.510，均P<0.001)；观察组治疗后前列腺液IL-6、IL-8、IL-10及TNF-α水平均低于对照组，差异有统计学意义(t=3.798、10.634、7.686、8.137，均P<0.001)；观察组治疗后血清PSA、NGF、TGF-β均低于对照组，差异有统计学意义(t=10.318、7.849、14.957，均P<0.001)；观察组治疗总有效率为93.33%，相比对照组的70.00%显著更高(χ2=5.455，P<0.05)；观察组、对照组不良反应总发生率分别为3.33%、6.67%，差异无统计学意义(χ2=0.351，P>0.05)。结论:TURP术后前列腺炎患者临床治疗中联合使用盐酸坦索罗辛胶囊、前列舒通胶囊，可明显提高患者症状改善、炎症反应控制效果，降低血清PSA、NGF、TGF-β水平，获得更理想的临床疗效，且患者的药物不良反应无明显增加。 |
| 关键词: 经尿道前列腺切除术 前列腺炎 酸坦索罗辛胶囊 前列舒通胶囊 炎性反应 |
| DOI：10.3969/j.issn.1007-6948.2021.03.014 |
| 投稿时间：2020-09-10 |
| 基金项目: |
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| Effect of Qianlie Shutong Capsule Combined with Tamsulosin Hydrochloride Capsule on the Level of Inflammatory Factors in Patients after TURP |
| ZHANG Zhi-jie |
| Department of Urology Surgery,Wuhan Red Cross Hospital,Wuhan, Hubei430000,China |
| Abstract: |
| Objective To evaluate the clinical effect of Qianlie Shutong capsule and Tamsulosin hydrochloride capsule in the treatment of patients with transurethral resection of the prostate prostatitis. Methods Sixty patients with prostatitis after TURP were admitted to our hospital from May 2018 to October 2019. The patients were divided into two groups by random number table.The control group was treated with Tamsulosin hydrochloride capsule and the observation group was treated with Tamsulosin hydrochloride capsule+Qianlie Shutong capsule.The symptoms, the improvement of inflammatory reaction, the total effect and the occurrence of adverse reactions were observed. Results The NIH-CPSI score, pain, quality of life score and total score in the observation group were significantly lower than those in the control group(t=4.518, 10.527, 14.889, 12.510, all P<0.001). The levels of IL-6, IL-8, IL-10 and TNF-αin the observation group were significantly lower than those in the control group(t=3.798, 10.634, 7.686, 8.137, all P<0.001). The levels of serum PSA, NGF and TGF-β in the observation group were significantly lower than those in the control group(t=10.318, 7.849, 14.957, all P<0.001). The total effective rate of the observation group was 93.33%, which was significantly higher than that of the control group (70.00%)(χ2=5.455，P<0.05). The total incidence of Adr in the observation group and the control group were 3.33% and 6.67% respectively(χ2=0.351, P>0.05). Conclusion Tamsulosin hydrochloride capsules and Qianlie Shutong capsules were used in the clinical treatment of patients with prostatitis after TURP, which can obviously improve the symptom, control the inflammatory reaction, lower the level of serum PSA, NGF and TGF-β, and get more ideal clinical curative effect. |
| Key words: Transurethral resection of the prostate prostattis acid tamsulosin capsules qianlieshutong capsule inflammatory reaction |
