| 摘要: |
| 目的:探究加味五苓散联合琥珀酸索利那新治疗血瘀水停型糖尿病神经源性膀胱(diabetic neurogenic bladder, DNB)的临床疗效。方法:采集2019年9月—2020年9月陕西中医药大学附属医院泌尿外科门诊及住院部符合血瘀水停型DNB患者80例，将其完全随机划分为对照组和治疗组2组，每组各选取40例纳入观察，两组患者均对血糖进行严格调控。对照组给予琥珀酸索利那新片 5 mg 口服 1次/d，治疗组在此用药方案上加用加味五苓散，设定4周为一个治疗疗程，连续用药2个疗程后评价两组患者治疗前后中医证候积分、膀胱残余尿量、尿流动力学相关指标及血糖的变化情况，以鉴定其疗效性。结果:在本次临床观察中，两组患者共完成观察病例80例，无脱落病例。达到疗程后，对照组的总有效率为55.0％，治疗组的总有效率为77.5％，通过对比临床有效率发现治疗组效果较好，差异具有统计学意义(P＜0.05)。其中，对比两组患者的中医证候积分后发现二者均较治疗前明显减低(P＜0.05)，治疗组的积分低于对照组(P＜0.05)，差异具有统计学意义；二者的尿流动力学指标、膀胱残余尿量均较之前改善(P＜0.05)，且治疗组较对照组改善更加明显，差异具有统计学意义(P＜0.05)。而二者的血糖状况(包括空腹血糖(FPG)、餐后2 h血糖(2hPG)及糖化血红蛋白(GHbA1)均较之前无明显变化，不具有统计学意义(P＞0.05)。结论:加味五苓散联合琥珀酸索利那新能缓解血瘀水停型糖尿病神经源性膀胱的症状。 |
| 关键词: 加味五苓散 琥珀酸索利那新 血瘀水停型 糖尿病神经源性膀胱 临床疗效 |
| DOI：10.3969/j.issn.1007-6948.2021.03.012 |
| 投稿时间：2020-12-01 |
| 基金项目:陕西省中医药管理局科研课题(2019-GJ-QT002) |
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| Clinical Observation of Modified Wuling Powder Combined with Thorley Succinate in the Treatment of Diabetic Neurogenic Bladder with Blood Stasis and Water Stagnation |
| CHEN Hang,ZHANG Yu-jun,DUAN Yu-hong |
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| Abstract: |
| Objective To explore the clinical efficacy of Jiawei Wuling Powder combined with soline succinate in the treatment of diabetic neurogenic bladder (DNB) with blood stasis and water stagnation. Methods 80 cases of patients with blood stasis and water stop type DNB from September 2019 to September 2020 in outpatient and inpatient department of urology department in the affiliated hospital of Shaanxi university of Traditional Chinese Medicine were collected. They were divided into control group and treatment group randomly. There were 2 groups, 40 cases were selected for observation in each group, and the blood glucose was strictly regulated in both groups. The control group was given 5 mg (po. qd) of solinasine succinate tablets, and the treatment group was given Jiawei Wuling Powder to this medication regimen. 4 weeks were set as a treatment course. After 2 consecutive courses of treatment, the scores of Chinese medical syndromes, residual urine volume, urodynamic related indicators and changes in blood glucose were evaluated to identify its efficacy. Results In this clinical observation, a total of 80 observation cases were completed in the 2 groups of patients, and there were no cases of shedding. After reaching the treatment course, the total effective rate of the control group was 55.0%, and the total effective rate of the treatment group was 77.5%. By comparing the clinical effective rate, it was found that the treatment group had better effects and the difference were statistically significant (P<0.05). Among them, after comparing the TCM syndrome scores of the two groups of patients, it was found that both of them were signi?cantly lower than those before treatment (P<0.05). The scores of the treatment group were lower than those of the control group (P<0.05), and the difference were statistically signi?cant. Urodynamic indexes and bladder residual urine volume were improved compared with those before (P<0.05). The treatment group improved more signi?cantly than that of the control group, which the difference was statistically signi?cant (P<0.05). The blood glucose status of the two (including fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG) and glycosylated hemoglobin (GHbA1) had no signi?cant changes compared with the previous ones, which were not statistically signi?cant (P>0.05). Conclusion Jiawei Wuling Powder combined with sorinsine succinate can alleviate the symptoms of neurogenic bladder of diabetes with blood stasis and water stagnation. |
| Key words: Jiawei Wuling Powder solinasine succinate blood stasis and water stagnation type diabetic |
