| 摘要: |
| 目的:观察芪柏愈疡油联合前列地尔注射液治疗下肢动脉硬化闭塞症坏疽创面的疗效。方法:将40名下肢动脉硬化闭塞症坏疽Ⅲ期1-2级患者随机分为治疗组及对照组各20例。在基础治疗的基础上对照组予复方紫草油纱条，治疗组使用芪柏愈疡油纱条，疗程均为28 d，比较其创面评分(疼痛、肉芽组织及渗液)，创面大小的变化情况，观察临床总有效率。结果:治疗组临床总有效率为90%，对照组为75% (P<0.05)。与治疗前相比，治疗后的治疗组创面缩小，踝肱指数增大，疼痛、渗液、肉芽组织评分降低(P<0.05)。与治疗前相比较，治疗后的对照组渗液评分无显著改变无明显变化，其余观察指标明显改善。治疗后，治疗组各项观察指标(除疼痛评分、踝肱指数)较治疗后对照组降低更为明显(P<0.05)。结论:芪柏愈疡油联合前列地尔注射液对下肢动脉硬化闭塞症坏疽Ⅲ期1-2级创面有明显疗效，可明显降低疼痛、肉芽组织及渗液评分，减小创面面积。 |
| 关键词: 芪柏愈疡油 脱疽 下肢动脉硬化闭塞症 前列地尔注射液 |
| DOI：10.3969/j.issn.1007-6948.2021.03.010 |
| 投稿时间：2020-11-14 |
| 基金项目: |
|
| Clinical Observation of Qibai Yuyang Oil Combined with Alprostadil Injection in the Treatment of Lower Extremity Arteriosclerosis with Gangrene |
| GAO Ya-nan,ZHAO Gang,JIA Zhen |
|
| Abstract: |
| Objective To observe the curative effect of Qibai Yuyang oil combined with Alprostadil injection on the wound of gangrene of arteriosclerosis. Methods Forty patients with stage III gangrene of lower extremity arteriosclerosis were randomly divided into treatment group (n=20) and control group (n=20) . On the basis of basic treatment, the control group was given compound Arnebiaeuchroma gauze, and the treatment group was given Qibai Yuyang gauze for 28 days. The total clinical efficiency was observed. Results The total effective rate was 90% in the treatment group and 75% in the control group (P<0.05) . Compared with the pretreatment group, the wound area was reduced, the ankle-brachial index was increased, the scores of pain, exudate and granulation tissue were decreased (P<0.05). Compared with the pre-treatment, there was no significant change in the osmotic score of the control group after treatment, and the other observation indexes were significantly improved. After treatment, all the indexes (except pain score and ankle-brachial index) in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qibai Yuyang oil combined with Alprostadil injection has obvious curative effect on the wound of grade 1-2 in Stage III of arteriosclerosis obliterans of lower limbs. |
| Key words: Qibai Yuyang oil gangrene arteriosclerosis obliterans of the lower extremity Alprostadil injection |
