| 摘要: |
| 目的:利用网络药理学研究方法预测茵陈赤小豆汤治疗深静脉血栓形成的作用机制。方法:利用中药系统药理学数据库和分析平台，挖掘茵陈赤小豆汤药物有效成分并预测其作用靶点，通过GeneCards、OMIM等数据库筛选出深静脉血栓形成的相关靶点。运用Cytoscape软件构建茵陈赤小豆汤治疗深静脉血栓形成的“成分-靶点-通路-疾病”网络，通过STRING数据库构建靶点蛋白相关作用网络并进行关键靶点的生物功能注释及通路分析。结果:茵陈赤小豆汤233个有效成分作用于119个靶点，涉及信号通路162条。结论:茵陈赤小豆汤可能通过介导糖基化终末产物与糖基化终末产物受体、白细胞介素(IL)-17、肿瘤坏死因子(TNF)等信号通路发挥干预深静脉血栓形成的作用。 |
| 关键词: 茵陈赤小豆汤 网络药理学 深静脉血栓形成 |
| DOI：10.3969/j.issn.1007-6948.2021.03.007 |
| 投稿时间：2020-12-14 |
| 基金项目:山东省中医药科技发展计划(2019-0559)；济南市第二届优秀卫生计生人才培养项目(济卫科外发〔2018〕8号)；济南市第三批“薪火传承231工程”培养项目(济中医药发〔2017〕11号)；济南市卫生健康系统青年岗位能手培养项目(济卫发〔2019〕1号)；济南市卫生健康委员会科技计划项目(2019-1-23) |
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| Study on the Mechanism of YinchenChixiaodou Decoction in the Treatment of Deep Venous Thrombosis Based on Network Pharmacology |
| WANG Yu-tao,ZHOU Miao-miao |
| Department of Peripheral Vascular Disease, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan (250014), China |
| Abstract: |
| Objective To predict the mechanism of YinchenChixiaodou decoction(YCCXD) in the treatment of deep venous thrombosis(DVT) by using the method of network pharmacology. Methods The targets of DVT were screened out byretrievingGeneCards, OMIM and other databases. The Traditional Chinese Medicine Systems Pharmacology database and the analysis platform were used to excavate the active components of YCCXD and predict their targets. Cytoscape was used to construct the“component-target-pathway-disease”network for the treatment of DVT. The protein-protein interaction network was constructed by STRING database, and the enrichment analysis of biological function annotation and pathways of the key targets were carried out. Results Two hundred and thirty-three active components of YCCXD may treat DVT by acting on 119 targets which involving 162 pathways. Conclusion The effective components of YCCXD may treat DVT by inhibiting the AGE-RAGE, IL-17, TNF signaling pathway. |
| Key words: YinchenChixiaodou decoction network pharmacology deep venous thrombosis |
