| 摘要: |
| 目的:观察围手术期脊柱结核患者的血清前白蛋白(PA)水平，初步探讨其对临床诊治的指导价值。方法:选取2013年6月—2017年6月我院收治的162名脊柱结核患者作为研究对象，以年龄大于65岁为老年组、小于65岁为非老年组，其中老年组35例，非老年组127例。男82例，女80例。化疗方案为3HREZ/5-7HRE，手术方法为I期病灶清除、自体植骨和坚强内固定。动态观察脊柱结核患者入院时、手术前、手术后2周、手术后4周的血清前白蛋白水平变化，对所得数据进行观察和统计学分析。结果:所有162例脊柱结核患者入院时、术前、术后2周、术后4周PA平均值:(0.14±0.03) g/L、(0.16±0.04) g/L、(0.22±0.04) g/L、(0.25±0.04) g/L。非老年组入院时、术前、术后2周、术后4周的PA平均值:(0.14±0.03)g/L、(0.17±0.03) g/L、(0.23±0.03) g/L、(0.25±0.03) g/L。老年组入院时、术前、术后2周、术后4周PA平均值:(0.12±0.04)g/L、(0.13±0.04) g/L、(0.18±0.05) g/L、(0.23±0.05) g/L；比较组间不同时间点的PA值，差异有统计学意义。比较同组不同时间点的PA值，差异有统计学意义。结论:围手术期脊柱结核患者的血清前白蛋白水平随病情好转逐渐升高，可以指导临床诊治，尚需进一步研究。 |
| 关键词: 脊柱结核 围手术期 血清前白蛋白 |
| DOI：10.3969/j.issn.1007-6948.2021.01.008 |
| 投稿时间：2020-03-25 |
| 基金项目:天津市海河医院科技基金项目(HHYY-201801)；天津市津南区科技计划项目(20190102) |
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| Changes in Serum Prealbumin following Spinal Tuberculosis Surgery |
| SUN Xiao-chen,TANG Liang,BAO Yu-cheng |
| TCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin 300350, China |
| Abstract: |
| Objective To explore the trend of changes in the serum prealbumin (PA) level in patients with spinal tuberculosis during perioperative period. Methods A retrospective study was performed by enrolling 162 patients with spinal tuberculosis who had been admitted to ourhospital from June 2013 to June 2017, including 82 males and 80 females. Included patients were then assigned to the elderly group (age ≥65 years, n=35) and the non-elderly group (age <65 years, n=127).The chemotherapy regimen was 3HREZ/5-7HRE, which in combination with preoperative anti-tuberculosis treatment and nutritional support for 3 to 4 weeks, as well asone-stage debridement and (or) bone graft fusion and internal fixation. The serum PA levels of patients with spinal tuberculosis at admission, prior to surgery and at 2 and 4 weeks after surgery were collected. Results There was a gradual increased trend in the PA level from admission to prior to surgery and at 2 and 4 weeks after surgeryin all patients [(0.14±0.03)g/L<(0.16±0.04)g/L<(0.22±0.04)g/L<(0.25±0.04)g/L]. The increase in the non-elderly group was much higher than that in the elderly group, which the difference was statistically significant (P<0.01). Conclusion Changes in serum PA level in patients with spinal tuberculosis during perioperative period are consistent with the trend of control of inflammation and nutrition improvement of nutrition.The relationship between the changes and the timing of surgery deserves to be observed in the future research. |
| Key words: Spinaltuberculosis perioperative period serum PA |
