| 摘要: |
| 目的:观察增生平联合四君子汤治疗食管低级别上皮内瘤变的临床疗效和安全性。方法:将105 例中医辨证为脾虚热瘀型的食管低级别上皮内瘤变患者随机分为三组，A 组(西药+ 增生平+ 四君子汤组)，B 组(西药+ 增生平组)，C 组(单纯西药组)，每组各35 例，分别给予对应药物进行干预，6 个月后观察患者的临床症状、食管黏膜在内镜下的变化和病理改变，以及治疗过程中不良反应发生情况。结果:A 组、B 组的疗效(100%，100%)均优于C 组(74.29%)，差异有统计学意义(P ＜ 0.05)，A组与B 组差异无统计学意义(P ＞ 0.05)。在内镜下黏膜改善程度上，A、B 组内镜改善评分(1.83±0.75，1.80±0.72)均显著高于C 组(1.43±0.61)，差异有统计学意义(P ＜ 0.05)，但A、B 两组差异无统计学意义(P ＞ 0.05)。在病理改善方面，A、B 两组有效率(41.18%、39.39%)均明显高于C 组(11.43%)，差异有统计学意义(P ＜ 0.05)但A、B 两组差异无统计学意义(P ＞ 0.05)。在治疗期间三组均未出现明显不良反应。结论:增生平能够有效改善脾虚热瘀型食管低级别上皮内瘤变患者的临床症状抑制低级别上皮内瘤变进展，且对食管黏膜有一定保护作用，值得临床推广应用。 |
| 关键词: 食管 低级别上皮内瘤变 增生平 四君子汤 |
| DOI：10.3969/j.issn.1007-6948.2020.06.023 |
| 投稿时间：2020-03-24 |
| 基金项目:天津市卫计委课题(2017039) |
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| Clinical Observation on the Treatment of Zengshengping and Sijunzi Decoction Combination Therapy in Low Grade Esophageal Intraepithelial Neoplasia with Spleen Deficiency and Heat Stasis |
| SUN Meng-zhao,LIAN Yu-fei,CUI Li-hong |
| Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin 300100, China |
| Abstract: |
| Objective To observe the clinical efficacy and safety of Zengshengping and Sijunzi decoction combination therapy in low grade esophageal intraepithelial neoplasia. Methods 105 patients with spleen deficiency and heat stasis, who were diagnosed with low grade esophageal intraepithelial neoplasia as well and they were randomly divided into three groups: group A (western medicine combined with Zengshengping and Sijunzi decoction), group B (western medicine combined with Zengshengping), group C (simple western medicine). There were 35 patients in each group and they were given corresponding drugs to intervene respectively. After 6 months, the patients; clinical symptoms, esophageal mucosa changes under endoscopy and pathological changes, as well as adverse reactions during the treatment were observed. Results The efficacies of group A and group B (100%, 100%) were both better than those of group C (74.29%) (P < 0.05), but there was no significant difference between group A and B (P > 0.05). In endoscopic mucosal improvement, endoscopic improvement scores in group A and B (1.83±0.75，1.80±0.72) were higher than group C (1.43±0.61)(P < 0.05), but there was no significant difference between group A and B (P > 0.05). In terms of pathological improvement, there was no statistically significant difference of the efficiency between group A and B (41.18%,39.39%) (P > 0.05), but the efficiencies of these groups were significantly higher than that of group C (11.43%)(P < 0.05). There was no obvious adverse reaction during the treatment. Conclusion Zengshengping can effectively improve the clinical symptoms of patients with low grade esophageal intraepithelial neoplasia, inhibit the progression of low grade intraepithelial neoplasia. It has a certain protective effect on esophageal mucosa,which is worthy of clinical application. |
| Key words: esophagus low grade intraepithelial neoplasia Zengshengping Sijunzi decoction |
