| 摘要: |
| 目的:探讨补中益气汤加减配合穴位贴敷治疗出口梗阻型便秘( OOC)的临床效果。方法:选取 2017年 7月— 2018年 8月我院收治的 104例 OOC患者，利用随机数字表法将其随机分成观察组( n=52)与对照组( n=52)。观察组采取补中益气汤加减配合穴位贴敷治疗，对照组给予聚乙二醇 4000散治疗，所有患者均治疗 4周。观察两组治疗后总有效率、治疗前后主要症状积分、肛管直肠动力学指标 [肛管静息压( ARP)、肛管缩榨压( ASP)、直肠最大耐受容量( RMTV)]、肠道菌群参数变化，不良反应发生情况。结果:观察组总有效率为 94.23%(49/52)，高于对照组的 73.08%(38/52)。两组治疗后各项主要症状(排便困难程度、排便时间、粪便性质)积分均较治疗前显著降低( P<0.05)，且观察组下降更明显(P<0.05)。观察组治疗后 ARP、ASP、RMTV值及肠杆菌、肠球菌数量均较治疗前显著减少( P<0.05)，双歧杆菌、乳酸杆菌数量均显著增加( P<0.05)。观察组不良反应发生率为 [7.69%(4/52)]，与对照组 [3.85%(2/52)]差异无统计学意义(P>0.05)。结论:补中益气汤加减配合穴位贴敷治疗 OOC能明显减轻患者症状，改善肛肠动力学，纠正肠道菌群失调，疗效确切，安全性高。 |
| 关键词: 补中益气汤加减 穴位贴敷 出口梗阻型便秘 肛肠动力学 肠道菌群 |
| DOI：10.3969/j.issn.1007-6948.2020.01.017 |
| 投稿时间：2018-11-17 |
| 基金项目: |
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| Therapeutic Effect of Modified Buzhong Yiqi Decoction Combined with Acupoint Application on Outlet Obstruction Constipation |
| MAO Gang,ZHAO Jing-wen |
| Department of Anorectal Diseases, Baoji Hospital of Traditional Chinese Medicine, Baoji721001, China |
| Abstract: |
| Objective To investigate the clinical efficacy of modified Buzhong Yiqi Decoction (BYD) combined with acupoint application on outlet obstructive constipation. Methods Totally 104 patients with outlet obstructive constipation (OOC) admitted in our hospital from July 2017 to August 2018 were divided into observation group (n=52) and control group (n=52) on the basis of random number table. The patients in observation group were treated with the combination of modified BYD and acupoint application, while the patients in control group were given macrogol 4000 powder. All patients were treated for 4 weeks. The total effective rate after treatment in both groups, the main symptom integral before and after treatment, anorectal dynamic indexes [anal resting pressure (ARP), anal squeeze pressure (ASP) and rectum maximum tolerable volume (RMTV)] and intestinal .ora parameters before and after treatment, and side effect were observed between the two groups. Results The overall effective rate of the observation group was 94.23% (49/52), much higher than that [73.08% (38/52)] of the control group (P<0.05). After treatment both groups saw a remarkable decrease in symptom (grade of defecation difficulties, defecation time and stool nature) integral as compared with that before treatment (P<0.05), and the decrease the observation group witnessed was more significant (P<0.05). After treatment the observation group saw an obvious drop in ARP, ASP, TMTV, enterobacteriaceae and nterococcus count (P<0.05), an increase in bi.dobacterium and lactobacillus count was observed compared with those before treatment (P<0.05), while the control group had no signi.cant difference in above aspects (P>0.05). The incidence of side effect of the observation group was 7.69% (4/52), without significant difference compared with the control group [3.85% (2/52)] (P>0.05). Conclusion In treating OOC the combination of modified BYD and acupoint application can significantly relieve symptoms in patients, improve anorectal dynamics and correct intestinal flora imbalance, proving to be effective and safe. |
| Key words: Modified Buzhong Yiqi Decoction acupoint application outlet obstructive constipation anorectal dynamics intestinal .ora |
