| 摘要: |
| 目的:探讨参丹散结胶囊联合电视胸腔镜辅助微创切口肺癌根治术( VAMT)治疗老年非小细胞肺癌( NSCLC)的临床治疗效果。方法:选取我院 2010年 5月—2012年 5月收治的 218例老年 NSCLC患者，随机分为观察组和对照组，每组 109例。对照组采用 VAMT治疗，观察组在此基础上另口服给予参丹散结胶囊，对照组则给予等剂量安慰剂连续治疗 3个月，治疗前后分别检测两组患者外周血中免疫功能指标( IgG、IgA、CD3+、CD4+及 CD8+)，肿瘤标记物( CYFRA21-1、 NSE、SCC及 CEA)含量，并评价两组患者的生活质量(社会功能、情绪功能、认知功能及躯体功能)。术后密切观察两组患者的术后并发症情况，主要包括术后疼痛、发热、咳嗽、出血、术后感染及心律失常。对所有患者进行为期 5年的随访，观察患者 1年、3年、5年的生存率、无进展生存期( PFS)及总生存时间( OS)。结果:治疗 3个月后，两组 IgG、IgA、 CD3+、CD4+及 CD8+含量均显著高于对照组(P<0.05)，CYFRA21-1、NSE、SCC及 CEA则均显著低于对照组(P<0.05)，且社会功能、情绪功能、认知功能及躯体功能评分均明显高于对照组( P<0.05)。治疗后，观察组术后疼痛、发热、咳嗽、出血、术后感染及心律失常等并发症的发生率均明显低于对照组( P<0.05)。远期疗效观察结果显示，观察组 1年、3年及 5年生存率均显著高于对照组( P<0.05)。结论:参丹散结胶囊联合 VAMT治疗老年 NSCLC的临床效果较好，且能够有效改善患者免疫功能，降低患者并发症的发生率。 |
| 关键词: 参丹散结胶囊 电视胸腔镜辅助微创切口肺癌根治术 老年 非小细胞肺癌 |
| DOI：10.3969/j.issn.1007-6948.2020.01.006 |
| 投稿时间：2019-02-13 |
| 基金项目:陕西省卫生厅科研项目 (2014-D27) |
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| Effects of Shendan Sanjie Capsule Combined with Video-assisted Minithoracotomy Surgery in Treatment of Elderly Non-Small Cell Lung Cancer |
| PENG Yan-cai,WEN hui,WANG Qian-ru |
| Department of Cardiothoracic and Oncology Surgery, Yulin First Hospital, Yulin (719000), China |
| Abstract: |
| Objective To investigate the clinical effects of Shendan Sanjie Capsule (SSC) combined with video-assisted minithoracotomy (VAMT) surgery in the treatment of elderly non-small cell lung cancer (NSCLC). Methods Totally 218 cases of elderly NSCLC patients treated in our hospital from May 2010 to May 2012 were randomly divided into observation group and control group, 109 cases in each group. The patients in control group weres treated by VAMT, while the patients in observation group were given SSC on the base of control group, the treatment time was 3 months and the isodose placebo was given in control group. Before and after treatment, the immunological function indicators (IgG, IgA, CD3+, CD4+ and CD8+), tumor markers (CYFRA21-1, NSE, SCC and CEA), and life quality scores (emotional function, social function, role function, cognitive function and physical function) in 2 groups were detected. After operation, the complications in 2 groups were closely observed, including postoperative pain, fever, cough, bleeding, postoperative infection and arrhythmia. After treatment, all patients were followed up for 5 years, and the survival rates were observed for 1, 3 and 5 years, along with the PFS and OS. Results Three months after the treatment, the levels of IgG, IgA, CD3+, CD4+ and CD8+ were significantly higher, while the CYFRA21-1, NSE, SCC and CEA levels were signi.cantly lower in observation group than which in control group (P<0.05), while the scores of emotional function, social function, role function, cognitive function and physical function were significantly higher in observation group than group (P<0.05). After the treatment, the rates of postoperative pain, fever, cough, bleeding, postoperative infection and arrhythmia were significantly lower in observation group than control group (P < 0.05). The 5 years followed up showed, 1, 3 and 5 years survival rates, progression-free survival (PFS) and overall survival (OS) in observation group were signi.cantly higher in observation group than control group (P <0.05). Conclusion SSC combined with VAMT surgery in the treatment of elderly NSCLC has a good effect, and could promote the immune function and reduce the postoperative complications in the patients. |
| Key words: Shendan Sanjie Capsule video-assisted minithoracotomy elderly non-small cell lung cancer |
