| 摘要: |
| 目的：探究犀角地黄汤联合创面清洗治疗糖尿病足的效果。方法：选取糖尿病足病人 56 例，根据随机数字法分为对照组及治疗组各 28 例，入组患者全部给予控制血糖处理；治疗组行犀角地黄汤联合创面清洗治疗，对照组给予中药汤药安慰剂联合创面清洗治疗，持续 3 个月，对比两组疗效、足背动脉内径、血管收缩期峰值流速、创面愈合率及血管内皮生长因子（vascular endothelial growth factor，VEGF）表达情况。结果：治疗组临床有效率 96.42%，对照组 75.00%（P<0.05）；治疗组足背动脉内径及血管收缩期峰值流速分别为 (0.19±0.014) mm、(31.79±2.15) mL/s，对照组分别为 (0.11±0.015) mm、(29.07±1.61) mL/s（P<0.05）；治疗组创面愈合 15 例，占 53.57%，对照组创面愈合 8 例，占 28.57%（P<0.05）；治疗组治疗后 VEGF 表达水平为 (128.34±39.35) ng/L，对照组为 (108.94±28.72) ng/L（P<0.05）。结论：犀角地黄汤联合创面清洗可以有效治疗糖尿病足。 |
| 关键词: 糖尿病足 犀角地黄汤 创面 血管内皮生长因子 |
| DOI：10.3969/j.issn.1007-6948.2019.06.016 |
|
| 基金项目: |
|
| Therapeutic Effect of Xijiao Dihuang Decoction Combined with Wound Cleansing Treatment on Diabetic Foot |
| GUO Ya-feng,ZUO Bai-jun,ZHANG Li-kang |
| Department of Orthopaedics, the First Hospital of Hebei Medical University, Shijiazhuang (050000), China |
| Abstract: |
| Objective To explore the clinical therapeutic effect of Xijiao Dihuang Decoction (XDD) combined with wound cleaning treatment on diabetic foot. Methods Fifty-six patients with diabetic foot were randomly divided into control group and treatment group, with 28 cases in each group. The patients in control group were routinely treated with Western medicine. The patients in treatment group were treated with XDD combined with wound cleaning. The treatment was continued for 3 months. After 3 months, the clinical efficacy, diameter of dorsal artery, blood flow velocity, wound healing rate and VEGF expression in two groups were compared. Results The clinical efficacy was 96.47% in the treatment group and 84.50% in the control group (P<0.05). The inner diameter and blood flow velocity of the dorsal artery in the treatment group were (0.19±0.014) mm and (31.79±2.15) mL/s, respectively. The inner diameter and blood flow velocity of the dorsal artery of the control group were (0.11±0.015)mm and (29.07±1.61)mL/s (P<0.05), respectively. The number of wound healing in the treatment group was 15 cases, accounting for 53.57%. There were 8 cases of wound healing in control group, accounting for 28.57% (P<0.05). The expression level of VEGF in the treatment group was (128.34±39.35) ng/L after treatment. The VEGF level before treatment was (108.94±28.72)ng/L after treatment in the control group (P<0.05). Conclusion XDD combined with wound cleaning treatment can effectively treat diabetic foot, and has certain clinical reference and promotion. |
| Key words: Diabetic foot Xijiao Dihuang Decoction wound vascular endothelial growth factor |
