| 摘要: |
| 目的：探讨原发性肝癌（HCC）患者血清微囊藻毒素（MC-LR）水平与患者临床分期及预后之间的关系。方法：通过 ELISA 法检测 HCC 患者血清 MC-LR 水平，并分析 HCC 患者血清 MC-LR 水平与临床特征及预后之间的关联。结果：HCC 患者血清 MC-LR 中位数为 0.69 ng/mL，不同临床分期 HCC 患者血清 MC-LR 水平分布有差异（P<0.001），且呈线性相关（P<0.001）；血清 MC-LR 水平与 HCC 患者年龄（P<0.01）、性别（P<0.05）、饮酒（P<0.05）、临床分期（P<0.001）、淋巴结转移（P<0.001）、远端转移（P<0.01）及 HBV 感染（P<0.05）相关，血清 MC-LR 水平越高，其生存期越短（P<0.05）。结论：血清 MC-LR 水平与 HCC 患者预后相关，血清 MC-LR 水平越高患者生存期越短。 |
| 关键词: 原发性肝癌 微囊藻毒素 预后 |
| DOI：10.3969/j.issn.1007-6948.2019.06.015 |
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| 基金项目: |
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| Correlation between Serum Microcystins and TNM Stage in Patients with Hepatocellular Carcinoma and its Effect on Prognosis |
| WANG Fu-tao,XU Bing,ZHANG Dian-peng |
| Department of General Surgery, Ankang(725000), China |
| Abstract: |
| Objective To study the relationship between the microcystins-LR (MC-LR) level in serum of hepatocellular carcinoma (HCC) patients and the clinical stage and prognosis of HCC. Methods ELISA assay was used to detect the level of MC-LR in serum and the relationship between the serum MC-LR level in HCC and the clinical characteristics and prognosis was detected and analyzed. Results The median of serum MC-LR level was 0.69 ng/mL, the serum MC-LR level in patients with different TNM stage was differently distributed (P<0.001), and there was a linear correlation between the MC-LR level and clinical stage (P<0.001). Serum MCLR level was correlated with age (P<0.05), sex (P<0.05), alcohol drinking (P<0.05), clinical stage (P<0.001), N stage (P<0.001), M stage (P<0.01), and HBV infection ( P<0.05). Patients with higher level of serum MC-LR would have a shorter overall survival time (P<0.05). Conclusion Serum MC-LR level was correlated with the prognosis of HCC, higher MC-LR serum level is associated with a shorter overall survival rate. |
| Key words: Hepatocellular carcinoma microcystin prognosis |
