| 摘要: |
| 目的 探讨补阳还五汤对于跟骨骨折术后伤口愈合的促进作用。方法:选取2021 年10 月—2023 年12 月我院收治的跟骨骨折住院患者60 例，分为治疗组(补阳还五汤结合罂粟碱)30 例，男29 例，女1 例；对照组(罂粟碱)30 例，男28 例，女2 例；所有患者均行跟骨外侧L 形切口切开复位钛板螺钉内固定术，术后常规引流48 h。记录并比较两组患者性别、年龄、骨折分型、手术时间、术后踝围径差、血清白细胞介素-1、碱性成纤维细胞生长因子、C 反应蛋白水平及切口愈合等级情况。结果:两组患者的性别、年龄、骨折分型、手术时间评分等方面无统计学差异，术后第5、7 天，治疗组踝关节围径差值分别为([ 4.06±0.83)cm、(3.42±0.66)cm]，较对照组肿胀明显减轻([ 4.71±0.87)cm、(3.93±0.75)cm]，差异有统计学意义(p<0.05)；术后第7 天，治疗组白细胞介素-1 水平为(31.68±3.54)ug/L，明显低于对照组(34.13±3.85)ug/L，术后第7 天，治疗组C 反应蛋白水平为(19.51±2.57)mg/L，明显低于对照组(21.36±2.64)mg/L，差异均有统计学意义(p<0.05)；术后第7 天，治疗组碱性成纤维细胞生长因子水平为(236.94±8.25)pg/mL，明显高于对照组(229.74±11.35)pg/mL，差异具有统计学意义(p<0.05)；治疗组愈合率高于对照组(96.67% vs 83.33%)，差异有统计学意义(p=0.025)。结论:跟骨骨折术后应用补阳还五汤治疗可促进切口愈合，减少并发症发生。 |
| 关键词: 跟骨骨折 骨折术后 伤口愈合 罂粟碱 中药 |
| DOI：10.3969/j.issn.1007-6948.2025.01.012 |
| 投稿时间：2024-06-13 |
| 基金项目:天津市卫生健康委、天津市中医药管理局课题(2021121) |
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| Clinical study on the treatment of postoperative wound healing disorderin calcaneal fracture with Buyang Huanwu decoction |
| WANG Bo-tao,REN Shou-ping,WANG Wen-jian |
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| Abstract: |
| Objective To evaluate the efficacy of Buyang Huanwu decoction in preventing delayed healing of incisions after calcaneal fracture surgery. Methods From October 2021 to December 2023, 60 patients with calcaneal fractures were enrolled and randomly divided into a treatment group (n=30) receiving Buyang Huanwu decoction and noscapine, including 29 males and 1 female; and a control group (n=30) receiving noscapine only,including 28 males and 2 females. All patients underwent a lateral L-shaped incision for open reduction and internal fixation with plates and screws. Routine drainage was performed for 48 hours postoperatively, and data on patient gender, age, fracture classification, operation time, postoperative ankle circumference difference, serum interleukin-1 (IL-1), basic fibroblast growth factor (bFGF), CRP levels, and incision healing grade were recorded.Statistical analysis was conducted. Results There were no statistically significant differences between the two groups regarding gender, age, fracture classification, and operation time. On postoperative days 5 and 7, the ankle circumference difference values in the treatment group were (4.06±0.83) cm and (3.42±0.66)cm, were lower than those in the control group (4.71±0.87)cm and (3.93±0.75)cm, which was statistically significant (p<0.05). On postoperative day 7, the level of IL-1 in the treatment group (31.68±3.54)ug/L was significantly lower than that in the control group (34.13±3.85)ug/L. On postoperative day 7,the level of CRP in the treatment group (19.51±2.57)mg/L was significantly lower than that in the control group (21.36±2.64) mg/L, showing a statistical difference (p<0.05). Similarly, the level of bFGF on postoperative day 7 in the treatment group (236.94±8.25) pg/mL was notably higher than that in the control group (229.74±11.35) pg/mL, also with a significant statistical difference (p<0.05). The healing rate of the treatment group was higher than that of the control group (96.67% vs 83.33%, p=0.025). Conclusion The application of Buyang Huanwu decoction combined with noscapine postoperatively in calcaneal fractures can promote incisional healing and reduce the occurrence of complications. |
| Key words: Calcaneal fracture postoperative wound healing noscapine Chinese herbal medicine |
