| 摘要: |
| 目的 探讨解毒承气汤联合生长抑素、肠梗阻导管治疗炎症性肠梗阻的疗效以及对免疫炎症、胃肠功能恢复的影响。方法:选择2020年6月—2023年6月我院收治的80例炎症性肠梗阻患者，按照随机数字表法分为两组。对照组(40例)采用生长抑素、肠梗阻导管治疗，观察组采用解毒承气汤联合生长抑素、肠梗阻导管治疗。比较两组疗效、胃肠功能恢复、免疫炎症、生活质量以及不良反应的差异。结果:观察组的治疗总有效率为90.00%，高于对照组的62.50%(P＜0.05)。观察组肠鸣音恢复时间、腹部症状消失时间、肛门首次排气时间、肛门首次排便时间均短于对照组(P＜0.05)，每日胃肠减压引流量及腹围缩小长度大于对照组(P＜0.05)。观察组治疗后外周血辅助性T细胞(Th)1占比，血清干扰素-γ(IFN-γ)水平，胃肠道生活质量指数(GIQLI)评分高于对照组(P＜0.05)，外周血Th2占比，血清白细胞介素(IL)-4水平低于对照组(P＜0.05)。结论:解毒承气汤联合生长抑素、肠梗阻导管治疗炎症性肠梗阻可促使胃肠功能恢复，改善免疫，抑制炎症反应，提高临床疗效和患者生活质量。 |
| 关键词: 炎症性肠梗阻 解毒承气汤 生长抑素 肠梗阻导管 免疫 炎症 胃肠功能 |
| DOI：10.3969/j.issn.1007-6948.2024.02.018 |
| 投稿时间：2023-10-05 |
| 基金项目:秦皇岛市科技局项目(202301A029) |
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| Clinical observation of Jiedu Chengqi decoction in the treatment of early postoperative inflammatory intestinal obstruction |
| LIU Jing-rui,YANG Jing-na,YUAN Da-wei |
| Qinhuangdao Traditional Chinese Medicine Hospital ,Qinhuangdao ,Hebei 066000，China |
| Abstract: |
| Objective To investigate the efficacy of Jiedu Chengqi decoction combined with somatostatin and intestinal obstruction catheter in the treatment of inflammatory intestinal obstruction and the effect on immune inflammation and gastrointestinal function recovery. Methods 80 patients with inflammatory ileus admitted to our hospital from June 2020 to June 2023 were selected and divided into two groups by random number table method. The control group (40 cases) was treated with somatostatin and intestinal obstruction catheter, and the observation group was treated with Jiedu Chengqi decoction combined with somatostatin and intestinal obstruction catheter. The effects, gastrointestinal function recovery, immune inflammation, quality of life and adverse reactions were compared between the two groups. Results The total effective rate of observation group was 90.00%, which was higher than that of control group 62.50% (P < 0.05). The recovery time of bowel sound, the time of disappearance of abdominal symptoms, the time of first anal exhaust, the time of first anal defecation in the observation group were shorter than those in the control group (P < 0.05), and the daily gastrointestinal decompression drainage volume and abdominal circumference reduction length were greater than those in the control group (P < 0.05). After treatment, the proportion of Th1 in peripheral blood, serum IFN-γ level and GIQLI score in the observation group were higher than those in the control group (P < 0.05), and the proportion of Th2 in peripheral blood and serum IL-4 level in the control group were lower than those in the control group (P < 0.05). Conclusion Jiedu Chengqi decoction combined with somatostatin and intestinal obstruction catheter in the treatment of inflammatory intestinal obstruction can promote the recovery of gastrointestinal function, improve immunity, inhibit inflammatory response, and improve clinical efficacy and quality of life of patients. |
| Key words: Inflammatory intestinal obstruction Jiedu Chengqi decoction somatostatin intestinal obstruction catheter immunity inflammation gastrointestinal function |
