| 摘要: |
| 目的 观察扶正生肌汤对低位肛瘘患者的临床效果。方法:选取2020年6月—2021年1月我院收治的116例低位肛瘘患者，采用随机数字表法分为对照组和研究组，每组各58例。两组患者均行肛瘘切开肌层缝合内口引流术，对照组术后给予常规治疗，研究组术后在常规治疗的基础上另给予扶正生肌汤治疗。对比两组患者的创面愈合率、新生肉芽情况、临床疗效、炎性因子、生长因子、肛门功能、肛管直肠压力及安全性。结果:研究组术后1周、2周创面愈合率、新生肉芽评分均高于对照组(P<0.05)。研究组总有效率高于对照组(P＜0.05)。研究组术后2周降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均低于对照组(P<0.05)。研究组术后2周血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平均高于对照组(P<0.05)。两组患者术后2周肛门功能评分、肛管最大收缩压对比，差异无统计学意义(P＞0.05)；研究组术后2周肛管静息压高于对照组(P<0.05)。两组患者治疗期间均无明显不良反应。结论:扶正生肌汤治疗低位肛瘘患者可促进术后创面愈合，提高临床疗效，调节炎性因子、生长因子水平，保护肛门功能，且安全可靠。 |
| 关键词: 低位肛瘘 肛瘘切开肌层缝合内口引流术 扶正生肌汤 肛门直肠功能 创面愈合 |
| DOI：10.3969/j.issn.1007-6948.2024.02.006 |
| 投稿时间：2023-05-08 |
| 基金项目:张家口市重点研发计划项目(2121117D) |
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| of Fuzheng Shengji Tang on anorectal function and wound healing in patients with low anal fistula |
| LIU Xiao-jun,ZHANG Xiao-ting,CAI Li-dan |
| Department 3 of Proctology, Zhangjiakou Fifth Hospital, Zhangjiakou 075000, China |
| Abstract: |
| Objective To observe the clinical effect of Fuzheng Shengji Tang on patients with low anal fistula. Methods 116 patients with low anal fistula admitted to our hospital from June 2020 to January 2021 were selected and divided into control group and study group by random number table method, each group consisted of 58 cases. Both groups underwent anal fistulotomy with myocutaneous suture and internal drainage, and the control group were given conventional treatment after the operation, while the study group were given Fuzheng Shengji Tang on top of the conventional treatment after the operation.The wound healing rate, new granulation, clinical efficacy, inflammation and inflammation in the two groups were investigated. The wound healing rate, new granulation, clinical efficacy, inflammatory factor, growth factor, anal function, anorectal pressure and safety were compared between the two groups. Results The trauma healing rate and new granulation score were higher in the study group than in the control group at 1 and 2 weeks after surgery (P<0.05). The total effective rate of the study group was higher than that of the control group (P<0.05). Calcitoninogen (PCT), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels at 2 weeks postoperatively were lower in the study group than in the control group (P<0.05). The levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) were higher in the study group than in the control group at 2 weeks postoperatively (P<0.05). There was no statistically significant difference in the anal function score and maximum systolic pressure of the anal canal between the two groups at 2 weeks postoperatively (P>0.05). The resting anal canal pressure at 2 weeks postoperatively was higher in the study group than in the control group (P<0.05). There were no significant adverse reactions during treatment in both groups. Conclusion Fuzheng Shengji Tang can promote postoperative wound healing, improve clinical efficacy, regulate the levels of inflammatory factors and growth factors, and protect anal function, and is safe and reliable. |
| Key words: Low anal fistula anal fistula incision and myocutaneous suture internal drainage Fuzheng Shengji Tang anorectal function wound healing |
