| 摘要: |
| 目的 探讨泻火解毒止痛汤联合复方黄柏液涂剂在肛周脓肿根治术后中的应用效果。方法:选取2021年6月—2023年6月唐山市中医医院收治的104例肛周脓肿患者，患者均进行肛周脓肿根治术治疗，术后采用随机数字分为两组，对照组(35例)采用复方黄柏液涂剂治疗，联合组(34例)采用泻火解毒止痛汤联合复方黄柏液涂剂治疗。治疗10 d后评估两组临床疗效、中医症候积分、炎症因子水平及安全性。结果:联合组总有效率高于对照组(97.05% vs 74.29%，P<0.05)。治疗后，联合组中医症候积分包括灼热疼痛、肉腐成脓、全身发热、舌红苔黄均低于对照组[(1.65±0.44)分，(1.78±0.46)分，(1.83±0.42)分，(1.90±0.47)分vs (2.05±0.51)分，(2.18±0.55)分，(2.32±0.57)分，(2.49±0.46)分] (P<0.05)。治疗后，联合组炎症因子白细胞介素-17A(IL-17A)、前列腺素E2(PGE2)、CXC 趋化因子配体13(CXCL13)水平均低于对照组[(43.31±5.94) ng/mL，(19.48±3.41) ng/mL，(71.43±8.14) ng/mL vs (51.25±6.28) ng/mL，(25.63±4.11) ng/mL,(82.12±9.02)ng/mL](P<0.05)。两组患者不良反应发生率无统计学差异(14.71% vs 8.57%，P>0.05)。结论:泻火解毒止痛汤联合复方黄柏液涂剂在肛周脓肿根治术后有良好应用效果，可减轻患者主要中医症候，降低炎症因子水平。 |
| 关键词: 肛周脓肿 泻火解毒止痛汤 复方黄柏液涂剂 疗效 炎症因子 |
| DOI：10.3969/j.issn.1007-6948.2024.02.002 |
| 投稿时间：2023-10-10 |
| 基金项目:河北省中医药管理局科研计划项目(2024151) |
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| Application effect of xiehuo Jiedu Zhitong Decoction combined with compound Huangbai liquid coating after radical treatment of perianal abscess |
| ZHAO Ya-nan，CHAI Xin-ling，WANG Jiao-te |
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| Abstract: |
| Objective To investigate the effect of xiehuo Jiedu Zhitong Decoction combined with compound Huangbai liquid in the treatment of perianal abscess after radical treatment. Methods 104 patients with perianal abscess admitted to Tangshan Traditional Chinese Medicine Hospital from june 2021 to june 2023 were selected. All patients were treated with perianal abscess radical resection. They were divided into: control group (35 cases) was treated with compound Huangbai liquid coating, combined group (34 cases) was treated with Xiehuo Jiedu Zhitong decoction combined with compound Huangbai liquid coating. After 2 weeks, the clinical efficacy, TCM syndrome score, inflammatory factors and treatment safety of the two groups were evaluated. Results The overall efficacy of the combination group was higher than that of the control group (97.05% vs 74.29%, P<0.05). After treatment, the TCM symptom scores of the combination group, including burning pain, flesh rotting into pus, systemic fever, and tongue redness and yellow coating, were lower than those of the control group [(1.65±0.44) points, (1.78±0.46) points, (1.83±0.42) points, (1.90±0.47) points vs (2.05±0.51) points, (2.18±0.55) points, (2.32±0.57) points, and (2.49±0.46) points] (P<0.05). After treatment, the levels of inflammatory factors interleukin-17A (IL-17A), prostaglandin E2 (PGE2), and CXC chemokine ligand 13 (CXCL13) in the combination group were lower than those in the control group [(43.31±5.94) ng/mL, (19.48±3.41) ng/mL, (71.43±8.14) ng/mL vs (51.25±6.28) ng/mL, (25.63±4.11) ng/mL (82.12±9.02) ng/mL] (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients (14.71% vs 8.57%, P>0.05). Conclusion Xiehuo Jiedu Zhitong Decoction combined with compound Huangbai liquid can relieve the main symptoms of traditional Chinese medicine, reduce the level of inflammatory factors. |
| Key words: Perianal abscess purging fire and detoxifying analgesic decoction compound yellow cedar liquid coating clinical effect inflammatory factors |
