| 摘要: |
| 目的 观察扶正和营方治疗重度糖尿病足溃疡合并营养不良的临床效果。方法:选取2022年6月—2023年1月我院脉管科收治的重度糖尿病足溃疡合并营养不良患者73例，随机分为试验组36例，对照组37例。试验组给予常规治疗加扶正和营方，对照组给予常规治疗加复方氨基酸胶囊，疗程均为28 d。比较两组创面愈合总有效率、中医症候积分、控制营养状态评分、创周护场及创面肉芽Ⅰ、Ⅲ型胶原蛋白。结果:试验组创面愈合总有效率为97.22%，高于对照组的75.68%(P＜0.05)。试验组降低中医症候积分、改善控制营养状态评分较对照组更明显(P＜0.05)；试验组创周护场形成有效率为88.89%，高于对照组的67.57%(P＜0.05)，且试验组降低创周四畔皮色、肿势、温度、疼痛积分优于对照组(P＜0.05)；与对照组相比，试验组能显著促进Ⅰ、Ⅲ型胶原蛋白表达(P＜0.05)。结论:扶正和营方治疗重度糖尿病足溃疡合并营养不良既能改善营养状况，缓解患者气血两虚证，又能促进创周护场形成，改善创面肉芽组织状态，促进创面愈合，且未见明显的不良反应事件，值得临床推广应用。 |
| 关键词: 糖尿病足溃疡 营养不良 扶正和营方 |
| DOI：10.3969/j.issn.1007-6948.2023.05.013 |
|
| 基金项目:上海市十三五临床重点专科(中医外科) |
|
| Clinical efficacy on Fuzheng Heying Formula treatment of severe diabetic foot ulcer complicated with malnutrition |
| ZHU Yan-dan,CAO Ye-min,YANG Jian-fei |
| Department of Vasculature, Shanghai TCM Integrated Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China |
| Abstract: |
| Objective To observe the clinical efficacy of Fuzheng Heying Formula in the treatment of severe diabetic foot ulcer complicated with malnutrition. Methods From June 2022 to January 2023, 73 patients with severe Diabetic foot ulcer and malnutrition in our hospital were randomly divided into 36 cases in the test group and 37 cases in the control group. The test group applied Fuzheng Heying Formula on the basis of routine treatment and the control group applied compound amino acid capsule on the basis of routine treatment. The course of treatment was 28 days. The total effective rate of wound healing, TCM symptom score, control of nutritional status score, periwound nursing field and wound granulation type Ⅰ and Ⅲ collagen were compared between the two groups. Results The total effective rate of wound healing in the test group was 97.22%, which was higher than that of the control group at 75.68% (P < 0.05). The test group was more significant (P < 0.05) than the control group in reducing the TCM symptom score and improving the control nutritional status score; The efficiency of periwound field formation in the test group was 88.89 %, which was higher than that of the control group at 67.57% (P < 0.05), and the test group was better than the control group in reducing the skin colour, swelling potential, temperature and pain score on the Sipan of the wound (P < 0.05); The test group significantly promoted the expression of type Ⅰ and Ⅲ collagen compared to the control group (P < 0.05). Conclusion The treatment of severe diabetic foot ulcer complicated with malnutrition with Fuzheng Heying Formula can not only improve the patient's nutritional status and alleviate the deficiency of both qi and blood, but also promote the formation of periwound protective field, improve the state of wound granulation tissue and promote wound healing, and no significant adverse events have been observed, which is worthy of clinical promotion. |
| Key words: Diabetic foot ulcer malnutrition Fuzheng Heying formula |
