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肺炎型肺癌中 EGFR 基因突变的影像学及临床特点
吕军,张洪,宋振春,王星,梁硕
0
天津市胸科医院放射科(天津 300222)
摘要:
目的:探讨肺炎型肺癌(P-LC)与 EGFR 基因突变的关系,分析 P-LC 不同 CT 征象与 EGFR 基因突变的相关性, 为临床诊治提供影像学评估。方法:收集经过 EGFR 基因检测具有完整临床及影像学资料的 187 例肺腺癌患者,其中 37 例P-LC,EGFR 有效突变组 9 例,非有效突变组 28 例。采用多元分析,系统评价临床资料及病变的 CT 影像特点,并分析其与 EGFR 基因突变的相关性。结果:P-LC 中 EGFR 突变组与对照组相比,性别、吸烟指数无显著差异(P > 0.1)。P-LC表现为轻度或中等程度强化;其常见 CT 征象为血管造影征(62%)、枯枝征(57%)。P-LC 的 EGFR 有效突变组与对照组相比,易出现非肿瘤叶结节(P < 0.05),OR 值 19.239(1.306—283.439)。结论:P-LC 中 EGFR 有效突变与性别、吸烟情况关系不大。P-LC 具有一定的CT 影像学特点,P-LC中 EGFR 有效突变组与对照组相比,易出现非肿瘤叶肺结节。
关键词:  肺炎型肺癌  表皮生长因子受体  突变  影像学特点
DOI:10.3969/j.issn.1007-6948.2019.02.004
基金项目:天津市科技计划项目(18ZXZNSY00400)
Radiogenomic and Clinical Characteristics of EGFR Gene Mutations in Pneumonic-type Lung Cancer
LV Jun,ZHANG Hong,SONG Zhen-chun,WANG Xing,LIANG Shuo
Medical Imaging Department, Tianjin Chest Hospital, Tianjin (300222), China
Abstract:
Objective To investigate the relationship between pneumonic-type lung carcinoma (P-LC) and EGFR gene mutation, and further analyze the correlation etween different CT signs of P-LC and EGFR gene mutation, so as to provide imaging evaluation for clinical diagnosis and treatment. Methods Totally 187 cases of lung adenocarcinoma with complete clinical and imaging data were collected. There were 37 P-LC patients, 9 in effective mutation group and 28 in non-effective mutation group. Multivariate analysis was used to evaluate the clinical data, radiogenomic characteristics and CT imaging features of the lesions. Results There was no signi?cant difference in gender and smoking index between EGFR mutation group and control group in P-LC (P > 0 . 1 ). P-LC showed mild or moderate enhancement. The common CT signs were angiography ( 62 %) and withered branches (57%). In all 37 cases of P-LC, the patients in EGFR effective mutation group were more likely to have non-tumor nodules than those in the ineffective mutation group, P<0.05, with OR value of 19.239, (1.306— 283.439) Conclusion The effective mutation of EGFR in P-LC is not related to gender and smoking. P-LC has certain CT imaging characteristics. Compared with the control group, the patients in EGFR effective mutation group in P-LC is prone to produce non-tumor lobar pulmonary nodules.
Key words:  Pneumonia-type lung cancer  epidermal growth factor receptor  mutation  imaging features

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