Medical Imaging Department, Tianjin Chest Hospital, Tianjin (300222), China
Abstract:
Objective To investigate the relationship between pneumonic-type lung carcinoma (P-LC) and EGFR gene mutation, and further analyze the correlation etween different CT signs of P-LC and EGFR gene mutation, so as to provide imaging evaluation for clinical diagnosis and treatment. Methods Totally 187 cases of lung adenocarcinoma with complete clinical and imaging data were collected. There were 37 P-LC patients, 9 in effective mutation group and 28 in non-effective mutation group. Multivariate analysis was used to evaluate the clinical data, radiogenomic characteristics and CT imaging features of the lesions. Results There was no signi?cant difference in gender and smoking index between EGFR mutation group and control group in P-LC (P > 0 . 1 ). P-LC showed mild or moderate enhancement. The common CT signs were angiography ( 62 %) and withered branches (57%). In all 37 cases of P-LC, the patients in EGFR effective mutation group were more likely to have non-tumor nodules than those in the ineffective mutation group, P<0.05, with OR value of 19.239, (1.306— 283.439) Conclusion The effective mutation of EGFR in P-LC is not related to gender and smoking. P-LC has certain CT imaging characteristics. Compared with the control group, the patients in EGFR effective mutation group in P-LC is prone to produce non-tumor lobar pulmonary nodules.
