| 摘要: |
| 目的：通过药效学研究，探讨丹芪偏瘫胶囊中黄芪和赤芍用于治疗缺血性脑血管病急性期的最优配伍比例。方法： 选择黄芪和赤芍四种不同的配伍比例，以颈动脉血栓形成时间为检测指标，筛选出一个有效样品。再选用健康 Wistar 大鼠， 制备高粘滞血症大鼠模型作为模型对照组，分别给药 2.5、5、10 mL/kg 作为低、中、高剂量组，观察黄芪- 赤芍浓缩液不同剂量组对高粘滞血症大鼠血液黏度和血浆纤维蛋白原含量的影响。结果：通过黄芪和赤芍不同配伍比例组合研究发现， 延长大鼠颈动脉血栓形成时间效果最佳的黄芪和赤芍配伍比例为 1:3。以此比例制成的浓缩液不同剂量对大鼠血液黏度的影响中发现，中、高剂量组可明显降低各切变速率下的全血黏度；低、中、高剂量组均明显降低红细胞压积至（48.1±4.3）%、（47.5±3.4）%、（42.2±2.4）%，并随剂量增加，作用增强。高剂量组可明显降低血浆纤维蛋白原含量至（1.3±0.3）g/L。结论：黄芪和赤芍剂量配伍比例为 1:3，给药剂量为10 mL/kg 时具有明显的活血作用。 |
| 关键词: 黄芪 赤芍 剂量配伍 给药剂量 药效学 |
| DOI：10.3969/j.issn.1007-6948.2019.02.003 |
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| 基金项目:西青区科技创新专项计划项目（XQCXZX2012- 006）；西青区科技型中小企业发展专项资金项目（XQKC2013-022） |
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| Optimized Compatibility Ratio of Radix Astragali and Radix Paeoniae Rubra based on Pharmacodynamics Study |
| MENG Meng,LI Jin,CHEN Tao,LI Zheng,CUI Wei-li |
| The First Hospital Afflilated of Tianjin Chinese Medical University, Tianjin (300193), China |
| Abstract: |
| Objective To explore the optimal compatibility ratio of Radix Astragali and Radix Paeoniae Rubra in Danqi Hemiplegia Capsule for treating the acute stage of ischemic cerebrovascular disease. Methods Four different compatible proportions of Radix Astragali and Radix Paeoniae Rubra were chosen, with carotid thrombosis time as testing index, a valid sample was selected. Then healthy Wistar rats were selected for the preparation of hyperviscosity rat model, and the dosages of 2 . 5 , 5 and 10 mL/kg were given respectively as the low-, mid- and high-dose groups, to observe the effects of different dosages of Astragalus membranaceus and Radix Paeoniae Rubra on the blood viscosity and plasma fibrinogen content of hyperviscosidemia rats. Results When the compatibility ratio of Radix Astragali and Radix Paeoniae Rubra was 1:3, the time of carotid artery thrombosis could be signi?cantly prolonged. The effects of different doses of the concentrate on the blood viscosity were found that the mid- and high-dose concentrate signi?cantly decreased the whole blood viscosity at different shear rates, and the low-, mid- and high-dose concentrate significantly reduced the hematocrit to ( 48 . 1 ± 4. 3)%, ( 47. 5 ± 3 . 4 )%, and ( 42 . 2 ± 2 . 4 )%. As the dose increased, the effect was enhanced. High dose group could signi?cantly reduce plasma ?brinogen content to (1.3±0.3) g/L.Conclusion The compatibility ratio of Radix Astragali and Radix Paeoniae Rubra is 1:3, and the dosage of 10 mL/kg is obviously effective in promoting blood circulation. |
| Key words: Radix Astragali Radix Paeoniae Rubra dose compatibility dosage pharmacodynamics |
