Rehabilitation Center, Bone Injury, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan (442000), China;Nanguan Baicaotang Traditional Chinese Medicine Clinic, Changchun City, Jilin Province (Changchun 130000);Department of Orthopaedics, Taihe Hospital of Shiyan City, Hubei Province (Affiliated Hospital of Hubei Medical College) (Shiyan 442000)
Abstract:
Objective To investigate the outcomes of diabetic osteoporosis treated based on syndrome differentiation. Methods The patients with diabetic osteoporosis (144 cases) were divided into 60 cases of liver and kidney deficiency syndrome, 40 cases of yin-yang deficiency syndrome and 44 cases of qi stagnation and blood stasis syndrome according to syndrome types of traditional Chinese medicine (TCM). Zishen Jiangtang Pills were given to patients with liver and kidney deficiency syndrome. Patients with yin-yang deficiency syndrome were treated with Tangukang Capsule, and patients with qi stagnation and blood stasis syndrome were treated with Guiwan Jiawei Capsule. Patients in all groups were treated and observed for 3 months. Outcomes of two groups were compared. Results After 3 months of treatment, the total effective rates of liver-kidney deficiency syndrome, yin-yang deficiency syndrome, and qi stagnation and blood stasis syndrome were 96.7%, 95.0% and 97.7%, respectively, without significant difference among the three syndrome types (P>0.05). The fasting blood glucose of patients in the above 3 groups after 3-month treatment were (5.38±1.49) mmol/L, (5.42±1.22) mmol/L and (4.39±1.74) mmol/L, respectively, and glycosylated hemoglobin levels were (6.10±0.58)%, (6.08±1.11)% and (6.13±1.42)%, respectively, which were significantly lower compared with those before treatment (P<0.05); the bone density of vertebral body 1–4 was significantly higher than that before treatment (P<0.05); serum interleukin-17 levels were (5.20±1.48) pg/nL, (4.99±2.19) pg/nL and (5.09±2.81) pg/nL, respectively, which were significantly lower than those before treatment (P<0.05), but there was no significant difference among the syndrome types (P>0.05). Conclusion Treatment of diabetic osteoporosis based on syndrome differentiation can inhibit the release of inflammatory cytokines, promote recovery of bony density, and decrease blood glucose and glycosylated hemoglobin levels, thereby improve therapeutic outcomes.
