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Effects of Xinlikang Capsule on Survival Time of Lewis Lung Cancer Model Mice and Its Mechanism of Action（除介冠词外，其他单词一律首字母大写，全部黑体） WANG Qing, QUE Zu-jun, TIAN Jian-hui.（姓在前，全部大写；名在后，首字母大写；三个字的名字，后两字用“-”连接，三个以上作者只保留三位，后接“et al.”） Institute of Oncology, Shanghai Academy of Traditional Chinese Medicine, Shanghai (200032), China （单位的写法：科室，单位名称，地区，邮编，国家，除介冠词外，其他单词一律首字母大写，全部斜体）
Abstract: Objective（首字母大写即可，黑体） To study the effects of Xinlikang Capsule on survival time and life quality of the model mice of pulmonary cancer metastasis of lung cancer, and explore the mechanism. Methods（首字母大写即可，黑体） Mouse model of pulmonary cancer metastasis of Lewis lung carcinoma (LLC) was established through tail intravenous injection, and were divided into saline group, low-dose Xinlikang group (0.08 g/mL) and high-dose Xinlikang group (0.40 g/mL), 10 mice in each group. The activity, food intake, hair glossiness and survival time were observed. Besides, the effects of Xinlikang on tumor-related signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NFκB) signal pathways were analyzed with luciferase assay. Results（首字母大写即可，黑体） The mice of saline group showed as depression, drowsiness, low glossy hair, low activity, little food intake and drinking, which was similar to mice in the low-dose Xinlikang group, but the mice in high–dose Xinlikang group showed as good spirit, glossy hair, more activity and more food intake and drinking. The median survival time was 17 d in saline group, 17.5 d in low concentration group, and 21 d in high-dose Xinlikang group which was significantly more than that in saline group (P<0.05). Xinlikang Capsule significantly inhibited the STAT3 and NFκB signal pathways. Conclusion（首字母大写即可，黑体） Xinlikang Capsule can prolong the survival time and improve the quality of life of mouse model with pulmonary cancer metastasis of lung cancer, maybe partly through inhibiting STAT3 and NFκB signal pathways.
Key words: （“K”要大写，两个单词之间要空一格，黑体） Xinlikang Capsule; lung cancer; model of pulmonary cancer metastasis of lung cancer; survival time; mechanism（第一个关键词首字母大写，除了特殊单词或专有名词以外，其余均小写）
