Therapeutic effect of Dachaihu decoction combined with phloroglucinol on patients with pancreatitis and its impact on serum IL-6 and D-D levels
WANG Jian-yu,LIU Ya-nan,CHEN Hai-yang
Abstract:
Objective To explore the therapeutic effect of Dachaihu decoction combined with phloroglucinol on patients with pancreatitis and its impact on serum levels of interleukin-6 (IL-6) and D-dimer (D-D). Methods A total of 64 patients with pancreatitis treated from April 2022 to April 2024 were selected as the observation subjects. All patients were randomly separated into a combination group (n=32) and a control group (n=32) according to the treatment method. The control group was treated with resorcinol on the basis of conventional treatment, and the combined group was treated with Dachaihu decoction on the basis of the control group. The clinical efficacy, levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), IL-6, blood calcium, blood amylase and urine amylase, D-D levels before and after treatment, and traditional Chinese medicine syndrome scores and adverse reactions were compared between two groups. Results The therapeutic effect of the combination group (93.75%) was greatly higher than that of the control group (65.62%) (P <0.05). After treatment, the decreases in seven scores of traditional Chinese medicine syndromes including short and red urine, bad breath, etc., hs-CRP, TNF-α, IL-6, blood amylase, urinary amylase and D-D in the combined group were greatly less than those in the control group (P <0.05). The blood calcium level of the two groups showed a great increase compared to before treatment, and the degree of increase in the combination group was higher than that in the control group (P <0.05). The adverse reactions in the combination group were greatly lower than those in the control group (P <0.05). Conclusion The combination of Dachaihu decoction and phloroglucinol can regulate the levels of inflammatory factors and amylase levels , improve coagulation levels, have high safety, and great effects.
