Effect of Beilou Sanjie Shuru decoction on patients with mammary gland hyperplasia of phlegm-stasis interaction type and its influence on serum estradiol and prolactin levels
SHU Yan,YANG Ai-wei,WAN Jian
Abstract:
Objective To investigate the effects of tamoxifen combined with Beilou Sanjie Shuru decoction on serum estradiol (E2), prolactin (PRL), TCM syndrome score, breast mass score and VAS score in patients with breast hyperplasia of phlegm and blood stasis intermingled type. Methods A total of 133 patients with breast hyperplasia of phlegm and blood stasis intermingled type admitted to hospital from February 2022 to February 2024 were selected and divided into control group (66 cases, treated with tamoxifen) and the observation group (67 cases, treated with tamoxifen combined with Beilou Sanjie Shuru decoction) according to the random number table method. The diameters of breast ducts and glandular thickness diameters, serum E2 and PRL levels, TCM syndrome scores, breast mass scores and VAS scores were compared between the two groups. Results The total clinical efficacy rate of the observation group was 97.01%, which was higher than that of the control group (84.85%) (χ2=4.519, P =0.046). After treatment, the glandular thickness and thickest diameter of the mammary duct in the observation group were lower than those in the control group (P < 0.05). The improvement effect of the TCM syndrome score in the observation group was significantly better than that in the control group (P <0.05). After treatment, the serum E2 and PRL levels in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P <0.05). After treatment, the breast mass score and VAS score of the observation group were significantly lower than those of the control group, and the differences were statistically significant (P <0.05). Conclusion Tamoxifen combined with Beilou Sanjie Shuru decoction can effectively treat patients with breast hyperplasia of phlegm and blood stasis intermingled type, reduce the thickness of the gland and the thickest diameter of the breast duct, regulate serum hormone levels, and improve the TCM syndrome score and breast mass score. It is worthy of clinical application.
