Effect of Zhitong Rushen decoction combined with potassium permanganate in the treatment of postoperative pain relief and swelling reduction after mixed hemorrhoids
TAN Peng-sheng,XIAO Qiang,ZHANG Yong-li
Department of Gastroenterology, Tinglin Hospital, Jinshan District, Shanghai201599, China
Abstract:
Objective To explore the efficacy and safety of Zhitong Rushen decoction combined with potassium permanganate in the treatment of pain relief and swelling reduction in patients after mixed hemorrhoids surgery. Methods The clinical data of 127 patients with mixed hemorrhoids who visited the hospital from February 2023 to May 2024 were retrospectively analyzed. They were divided into two groups according to different postoperative treatment methods, with 63 and 64 cases respectively. Group A was treated with potassium permanganate solution sitz bath after the operation, while group B was combined with the zhitong Rushen decoction after the operation. The pain disappearance time, the disappearance time of anal distension, the wound healing time, perianal edema and pain, serological indicators, anal function and safety of the two groups were compared. Results The disappearance time of pain, the disappearance time of anal distension, and the wound healing time of patients in group B were shorter than those in group A (P <0.05). After 1 and 2 weeks of treatment, the perianal edema scores and visual analogue scale (VAS) scores of the patients in both groups were significantly lower than those before treatment, and those in group B were even lower than those in group A (P <0.05). After 1 and 2 weeks of treatment, the levels of serum vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and type I collagen (COL-I) in both groups were significantly increased compared with those before treatment, and the level in group B was higher than that in group A (P <0.05), while the level of neuropeptide Y (NPY) was significantly decreased compared with that before treatment. Group B was lower than group A (P <0.05); After treatment, the scores of the defecation control scale (Kirwan) and the anal incontinence scale (Wexner) in both groups were significantly lower than those before treatment, and the score in group B was even lower than that in group A (P <0.05). The total incidence of complications in group B was lower than that in group A (P <0.05). Conclusion The combination of Zhitong Rushen decoction and potassium permanganate in the treatment of postoperative patients with mixed hemorrhoids can shorten the clinical symptoms and wound healing time, reduce perianal edema and pain, promote the growth of granulation tissue in the wound and the recovery of anal function, and has good safety.
