Curative effect of swelling-removing and healing-promoting decoction for medicated immersion on perianal abscess and its influences on vascular endothelial growth factor, epidermal cytokines and pH value in wound tissues
PENG Yun,SHA Jing-tao,YAO Jia
Abstract:
Objective To explore the curative effect of swelling-removing and healing-promoting decoction for medicated bath on perianal abscess and its effects on vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and pH value of wound tissues. Methods According to random number table, 123 patients undergoing radical surgery for perianal abscess in the hospital were divided into control group (n=61, routine treatment + normal saline immersion) and observation group (n=62, swelling-removing and healing-promoting decoction immersion added to control) from October 2023 to December 2024. All patients received for 2 weeks. The clinical efficacy, pain and edema scores, wound healing (bleeding, exudate, healing rate), wound tissue growth factors (VEGF, TGF-β1), pH values and adverse reaction incidence were compared. Results After 14 d of treatment, total clinical response rates was significantly higher in the observation group than the control group (100.0% vs 80.0%, P <0.05). After 7 d and 14 d of treatment, scores of wound pain and edema scores were significantly lower in the observation group than the control group, scores of wound bleeding and seepage were significantly lower in the observation group. After 14 d of treatment, the wound repair rate was higher in the observation group than the control group (P <0.05). After 7 d and 14 d of treatment, the levels of TGF-β1 and VEGF were higher in the observation group than the control group, and the pH value was lower in the observation group (P <0.05). During treatment, the difference in incidence of adverse reactions between the two groups was not statistically significant (P >0.05). Conclusion Swelling-removing and healing-promoting decoction for medicated immersion therapy can increase the total response rate of clinical treatment, promote wound repair, relieve pain, and shorten treatment cycle in patients with perianal abscess, with good safety.
