Therapeutic effect of self-made proctitis enema via rectal drip on ulcerative proctitis and its influence on serum interleukin-10 and monocyte chemoattractant protein-1 levels
CUI Shu-de,LI Xiao-hua,SHI Jie
Department of Proctology, Cangzhou Sino-Western Combination Hospital, Cangzhou061000, China
Abstract:
Objective To investigate the healing effect of a self-made proctitis enema formula rectal instillation combined with mesalazine enteric coated tablets in treating ulcerative proctitis (UP) and its impacts on levels of serum interleukin-10 (IL-10) and monocyte chemoattractant protein-1 (MCP-1). Methods Selecting 90 patients with UP who were treated in our hospital from March 2021 to December 2023, and were divided into treatment group (treatment plan: self-designed proctitis enema prescription combined with mesalazine enteric-coated tablets) and control group (treatment plan: mesalazine enteric-coated tablets) by random number table method, 45 cases each. The healing effect, inflammatory factors, intestinal barrier function indicators, traditional Chinese medicine syndrome scores, colonoscopy scores, inflammatory bowel disease questionnaire (IBDQ) scores, and adverse reactions of the two groups were compared. Results The total effective rate of the treatment group was higher than that of the control group (95.56% vs 80.00%, P <0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α) and MCP-1 in both groups decreased compared to before treatment, with a greater decrease observed in the treatment group (P <0.05); both groups showed an increase in IL-10 level, with a greater increase observed in the treatment group (P <0.05). After treatment, the levels of diamine oxidase (DAO) and D-lactate in both groups decreased compared to before treatment, with a greater decrease observed in the treatment group (P <0.05). After treatment, the scores of traditional Chinese medicine syndrome in both groups decreased compared to before treatment, and the decrease was larger in the treatment group (P <0.05). After treatment, both groups showed a decrease in rectal examination scores compared to before treatment, with the treatment group showing a greater decrease (P <0.05). Both groups showed an increase in IBDQ scores compared to before treatment, with the treatment group showing a greater increase (P <0.05). There was no statistically obvious difference in adverse reactions between the two groups (P >0.05). Conclusion The use of a self-made proctitis enema formula rectal instillation combined with mesalazine enteric coated tablets can improve the clinical symptoms of UP patients, reduce inflammatory reactions, and repair intestinal barrier function, with obvious healing effects.
