Clinical effect of the modified combination of Baitouweng decoction and Shaoyao decoction for enema treatment on ulcerative colitis with large intestine damp-heat
YU Huan,WU Ting-ting
Suzhou Hospital of Traditional Chinese Medicine, Suzhou 215008, China
Abstract:
Objective To explore the clinical efficacy of the modified combination of Baitouweng decoction and Shaoyao decoction plus or minus for enema treatment on ulcerative colitis with large intestine damp-heat. Methods A total of 96 ulcerative colitis with large intestine damp-heat patients admitted to our hospital from January 2023 to January 2025 were selected and divided into the oral administration group (n=48) and the combined group (n=48) according to the random number method. Patients in the oral administration group received modified oral administration of Baitouweng decoction and Shaoyao decoction plus or minus, while those in the combined administration group received addition enema treatment of Baitouweng decoction and Shaoyao decoction plus or minus on the basis of the treatment in the oral administration group. Comparing clinical efficacy of the two groups, the TCM symptom scores before and after treatment, the Baron endoscopic score, the modified Mayo activity index, the related indicators of serum intestinal mucosal barrier function, serum inflammatory factor levels as well as the adverse reaction occurrences. Results The total effective rate of the combined group was higher than that of the oral administration group (P <0.05). After treatment, the scores of various traditional Chinese medicine symptoms, Baron endoscopic score, modified Mayo activity index, serum intestinal mucosal barrier function-related indicators DAO, D-lactic acid, ET, and the levels of IL-6 and TNF-α in both groups were lower compared with before, with lower in the combined group than the oral administration group (P <0.05). The level of IL-10 was higher than that before treatment, while the combined group was higher than the oral administration group (P <0.05). No statistically significant difference was found in the occurrence of adverse reactions between the two groups (P =0.296). Conclusion The modified combination of Baitouweng decoction and Shaoyao decoction plus or minus for enema treatment can effectively treat ulcerative colitis of damp-heat type in the large intestine.
