| 摘要: |
| 目的 探究经尿道铥激光切除术联合五苓散及X线防护罩对浅表性膀胱肿瘤患者的术治疗效果及血清癌胚抗原(CEA)和细胞角蛋白19片段(Cyfra21-1)的影响。方法:回顾性选取2018年10月—2021年6月我院收治的102例浅表膀胱肿瘤患者，按照患者所接受的治疗方式不同分为观察组和对照组各51例，其中对照组采取经尿道铥激光切除术治疗，观察组在对照组基础上联合五苓散及X线防护罩，对比两组患者的手术情况、术后并发症发生情况及患者的复发情况。结果:两组均取得了一定的临床预期，观察组的术中出血量、手术时间、膀胱冲洗时间、导尿管留置时间及住院时间均显著短于对照组，差异有统计学意义(P<0.05)；治疗期间两组均未出现严重不可控的并发症和术后不良反应情况，观察组的尿路感染、尿道狭窄及切口感染发生率显著低于对照组，差异有统计学意义(P<0.05)；两组随访1年均未出现失访病例，观察组复发率5.88%，低于对照组的复发率19.61%，差异有统计学意义(P<0.05)。观察组患者疾病控制率(DCR)高于对照组(P<0.05)。治疗后，观察组CEA及Cyfra21-1水平均低于对照组(P<0.05)。结论:经尿道铥激光切除术联合五苓散及X线防护罩治疗浅表性膀胱肿瘤具有较好的临床有效性，且患者术后并发症发生率更低。 |
| 关键词: 铥激光 浅表性膀胱癌 经尿道铥激光切除术 五苓散 X线防护罩 复发率 手术效果 |
| DOI：10.3969/j.issn.1007-6948.2023.05.016 |
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| 基金项目:秦皇岛市重点科技研究计划(201602A260) |
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| Therapeutic effect of transurethral thulium laser resection combined with Wuling San and X-ray shield on patients with superficial bladder tumo |
| CHEN Wei，ZHAO Li-yan，LIU Wei |
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| Abstract: |
| Objective To explore the effect of transurethral thulium laser resection combined with Wuling San and X-ray shield on the surgical treatment of patients with superficial bladder tumor and the influence of serum carcinoembryonic antigen(CEA) and Cytokeratin 19 fragment(Cyfra21-1). Methods Retrospectively selected 102 patients with superficial bladder tumor admitted to our hospital from October 2018 to June 2021 as the subjects of this study. According to the different treatment methods received by patients, they were divided into the observation group and the control group, each with 51 cases. The control group was treated with transurethral thulium laser resection. The observation group, based on the control group, combined with Wuling San and X-ray protective shield, compared the operation, postoperative complications and recurrence of patients in the two groups. Results Both groups achieved certain clinical expectations. The intraoperative bleeding volume, operation time, bladder flushing time, Foley catheter retention time and hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). During the treatment period, neither group experienced severe uncontrollable complications or postoperative adverse reactions. The incidence of urinary tract infections, urethral strictures, and incision infections in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05); There were no lost cases during the one-year period, and the recurrence rate in the control group was 19.61%, while the recurrence rate in the observation group was 5.88%. The difference was statistically significant (P<0.05). The disease control rate(DCR) of the observation group was higher than those of the control group (P<0.05). After treatment, the levels of CEA and CYFRA21-1 in the observation group were lower than those in the control group (P<0.05). Conclusion Transurethral thulium laser resection combined with Wuling San Wan and X-ray shield has good clinical effectiveness in the treatment of superficial bladder tumors, and the incidence of postoperative complications of patients is lower. |
| Key words: holmium laser superficial bladder cancer transurethral holmium laser resection Wuling Powder X-ray shield recurrence rate surgical effect |
