| 摘要: |
| 目的:探讨金黄膏对急性阑尾炎腹腔镜阑尾切除术后胃肠功能和炎性因子的影响。方法:选择2018年8月—2020年7月本院收治的150例急性阑尾炎患者，随机分为对照组和观察组，各75例。对照组常规行腹腔镜阑尾切除术，观察组在腹腔镜术后加用金黄膏外敷。比较两组临床疗效、胃肠功能、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白CRP)、白细胞计数、中性粒细胞水平及并发症发生情况。结果:治疗后，观察组临床总有效率(85.33%)高于对照组(62.67%)，差异有统计学意义(P<0.05)；观察组GSRS评分、首次排气时间及肠鸣音恢复时间分别为(6.74±1.85)分、(23.49±6.30)h、(19.33±4.71)h，均低于对照组的(9.08±2.47)分、(30.08±7.22)h、(27.59±5.63)h，差异有统计学意义(P<0.05)；两组TNF-α、IL-6、CRP、白细胞计数及中性粒细胞水平均低于治疗前(P<0.05)，且观察组TNF-α、IL-6、CRP、白细胞计数及中性粒细胞水平分别为(37.53±6.12)pg/mL、(29.74±4.99)pg/mL、(7.88±2.19)mg/L、(7.69±0.97)×109 /L、(58.27±3.10)%，低于对照组的(56.49±8.51)pg/mL、(40.05±6.11)pg/mL、(12.07±2.63)mg/L、(10.87±1.53)×109 /L、(74.69±3.55)%，差异有统计学意义(P<0.05)；观察组疼痛、肠梗阻、切口感染、腹腔脓肿等并发症发生率(6.67%)低于对照组(20.00%)，差异有统计学意义(P<0.05)。结论:金黄膏用于急性阑尾炎腹腔镜阑尾切除术后患者，可改善患者临床疗效，促进患者胃肠功能的恢复，降低其炎性因子水平，且并发症发生率低，具有临床推广意义。 |
| 关键词: 金黄膏 腹腔镜手术 急性阑尾炎 肠胃功能 炎性因子 |
| DOI：10.3969/j.issn.1007-6948.2022.04.014 |
| 投稿时间：2021-08-08 |
| 基金项目:温州市科研项目(Y2020383) |
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| Effect of Jinhuang Ointment on Gastrointestinal Function after Laparoscopic Appendectomy for Acute Appendicitis |
| ZHANG Yi-ming,HAN Man-man,WANG Jiu-long |
| Department of General Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Whenzhou 325000, China |
| Abstract: |
| Objective To investigate the effect of Jinhuang Ointment on gastrointestinal function and inflammatory cytokines after laparoscopic appendectomy for acute appendicitis. Methods A total of 150 patients with acute appendicitis admitted to our hospital from August 2018 to July 2020 were selected as the research subjects. Prospective study analysis method was adopted, and the included patients were divided into control group and observation group according to random number table, with 75 cases in each group. Laparoscopic appendectomy was performed in the control group, and Jinhuang ointment was applied in the observation group after laparoscopic operation. The clinical efficacy, gastrointestinal function, the levels of Tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), C-reactive protein(CRP), white blood cell count, neutrophils and complications were compared between the two groups. Results After treatment, the total clinical effective rate of observation group (85.33%) was higher than that of the control group (62.67%) (P<0.05). The GSRS score, the first exhaust time and the recovery time of bowel sounds in the observation group were lower than those in the control group [(6.74±1.85), (23.49±6.30) h and (19.33±4.71) h respectively], which were lower than those in the control group [(9.08±2.47), (30.08±7.22) h and (27.59±5.63) h] (P<0.05). The levels of TNF-α, IL-6, CRP, WBC count and neutrophils in both groups were lower than those before treatment (P<0.05). The TNF-α, IL-6, CRP, white blood cell count and neutrophil level in the observation group [( 37 . 53 ±6 . 12 ) pg/mL,(29.74±4.99) pg/mL, (7.88±2.19) mg/L, (7.69±0.97) ×109/L, (58.27±3.10) %] were lower than those in the control group [(56.49±8.51) pg/mL, (40.05±6.11) pg/mL, (12.07±2.63) pg/mL, (10.87±1.53)× 109/L, (74.69±3.55) %] (P<0.05). The incidence of pain, intestinal obstruction, infection of incisional wound, abdominal abscess and other complications in the observation group (6.67%) was lower than those in the control group (20.00%) (P<0.05). Conclusion The Jinhuang ointment for laparoscopic surgery of acute appendicitis can improve the clinical effect, promote the recovery of gastrointestinal function, reduce the level of in.ammatory factors. The incidence of complications is low, which is of clinical signi.cance. |
| Key words: Jinhuang ointment laparoscopic surgery suppurative or perforated acute appendicitis gastrointestinal function in.ammatory cytokines |
