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苦柏液熏洗对低位单纯肛瘘术后创面愈合的临床研究
陈杰,郭坚,王晓凤,徐可,郭仕琪
0
盐城市中医院江苏盐城 224000
摘要:
目的:探讨苦柏液熏洗对低位单纯肛瘘术后创面愈合的临床疗效。方法:选取我院诊治的低位单纯肛瘘行手术切除患者 192例,随机分为研究组和对照组,每组 96例。对照组给予 1∶5000高锰酸钾溶液坐浴治疗,研究组给予苦柏液熏洗治疗,分别于术后第 1、7、14、21天观察两组的创面面积,创面纵径,创面分泌物评分,创面肉芽评分,创面水肿评分,创面疼痛评分,创面愈合率,创面细菌检出结果,于术后 1个月评价两组临床疗效,治疗前后血清炎性因子水平,血清 miR-495、miR-181c-5p表达水平。结果:研究组治疗后总有效率 85.42%高于对照组 69.79%,差异有统计学意义(P< 0.05);两组随着治疗周期延长,创面面积,创面纵径,各创面评分均降低,差异有统计学意义(P< 0.05);研究组后第 1、 7、14、21天创面面积,创面纵径,创面分泌物,创面肉芽,双面水肿,创面疼痛评分低于对照组,差异有统计学意义(P< 0.05)。两组创面愈合率随着治疗周期延长而逐渐增高,且研究组的创面愈合率显著高于对照组,差异有统计学意义(P< 0.05)。两组术后第 7天细菌检出结果比较,研究组检出率低于对照组,差异有统计学意义( P< 0.05)。治疗后两组血清炎性因子水平,血清 miR-155,miR-195表达水平均较治疗前降低,研究组低于对照组,差异有统计学意义( P< 0.05)。
关键词:  苦柏液  低位肛瘘  创面愈合  中药熏洗  临床疗效
DOI:10.3969/j.issn.1007-6948.2022.03.016
投稿时间:2021-10-15
基金项目:
Clinical Study of Kubai Liquid Fumigation and Washing on Wound Healing after Operation of Low-position Simple Anal Fistula
CHEN Jie,GUO Jian,WANG Xiao-feng
Anorectal Department, Yancheng Hospital of Traditional Chinese Medicine, Jiangsu 224000, China
Abstract:
Objective To explore the clinical effect of Kubai liquid fumigation and washing on wound healing after operation of low-position simple anal .stula. Methods A total of 192 patients with simple low anal fistula undergoing surgical resection were selected in our hospital and divided into study group (n=96) and control group (n=96) according to a random number table. The control group was given 1:5000 potassium permanganate (PP powder) solution for sitz bath treatment, and the study group was given Kubai solution fumigation and washing treatment. The wound area, wound longitudinal diameter, wound secretion score, wound granulation score, wound edema score, wound pain score, wound healing rate, wound bacterial detection results and the clinical efficacy on the 1st day, the 7th day, the 14th day and the 21st day after operation of the two groups were evaluated. One month after surgery, the clinical efficacy, levels of serum inflammatory factors, expression levels of serum miR-495 and miR-181c-5p before and after treatment of the two groups were evaluated. Results After treatment, the total effective rate of the study group was 85.42%, which was higher than that of the control group 69.79% (P< 0.05). As the treatment period was extended, the wound area, wound longitudinal diameter and wound scores of the two groups decreased (P< 0.05). In the control group, the wound area, wound longitudinal diameter, wound secretion, wound granulation, double-sided edema, wound pain score of the study group were lower than those of the control group on the 7th, 14th and 21st day after operation (P<0.05). The wound healing rate of the two groups gradually increased with the extension of the treatment period, and the wound healing rate of the study group was significantly higher than that of the control group (P<0.05). Comparison of the bacterial detection results on the 7th day after operation between the two groups, the detection rate of the study group was lower than that of the control group, which the difference was statistically signi.cant (P<0.05). After treatment, the levels of serum in.ammatory factors, serum miR-155 and miR-195 expression levels were lower than those before treatment, and the study group was lower than the control group, which the difference was statistically signi.cant (P<0.05). Conclusion Kubai liquid fumigation promotes postoperative wound healing in patients with low-position simple anal .stula, and the clinical effect is signi.cant.
Key words:  Kubai Liquid  low anal fistula  wound healing  Chinese medicine fumigation  clinical ef.cacy

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