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血竭散联合英夫利西单抗治疗克罗恩病的临床疗效观察
徐治中,杜骏,杨筱,何宗琦,文科,孙薛亮
0
南京中医药大学附属苏州市中医医院肛肠科江苏苏州 215000
摘要:
目的:观察血竭散联合英夫利西单抗( IFX)治疗克罗恩病( CD)的临床疗效。方法:回顾性分析 2017年 1月— 2021年 5月苏州市中医医院肛肠科确诊的 CD患者 59例,根据内科治疗方案分为治疗组(血竭散联合 IFX)27例和对照组(IFX)32例。观察两组治疗 14周时腹痛症状及评分、内镜缓解率、克罗恩病简化内镜评分( SES-CD)、临床缓解率、克罗恩病活动指数( CDAI)、IFX谷浓度、肿瘤坏死因子 -α(TNF-α)浓度、粪钙卫蛋白( FC)含量、血小板( PLT)计数、 D-二聚体( D-D)和纤维蛋白原( FIB)浓度。结果:治疗后,两组腹痛评分、 SES-CD评分、 CDAI评分、 FC含量、 PLT计数、D-D和 FIB浓度均低于治疗前,差异有统计学意义( P<0.05)。两组患者临床缓解率(96.3% vs 93.8%)和 CDAI评分
关键词:  血竭散  克罗恩病  血小板  纤维蛋白原  D-二聚体
DOI:10.3969/j.issn.1007-6948.2022.03.009
投稿时间:2021-09-11
基金项目:苏州市中西医结合科研基金项目( SYSD2020253)
Effect of Combination of Xue Jie San and Infliximab in Treating Crohn' s Disease
XU Zhi-zhong,DU Jun,YANG Xiao
Department of Colorectal Surgery, Suzhou TCM Hospital Af.liated to Nanjing University of Chinese Medicine, Suzhou 215000, China
Abstract:
Objective To observe the efficacy of combination of Xue Jie San and infliximab (IFX) for the treatment of Crohn' s disease (CD). Methods The prospectively collected data of CD patients who were admitted at Suzhou Hospital of Traditional Chinese Medicine between January 2017 and May 2021 were retrospectively analyzed. The patients were divided into treatment group and control group based on medical regimen. In treatment group (27 cases), patients were treated with combination of Xue Jie San and IFX as well as 32 patients in control group received IFX alone. Symptom and score of abdominal pain, endoscopic remission rate,
Key words:  Xue Jie San  Crohn' s disease  platelet  .brinogen  D-dimer

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