| 摘要: |
| 目的:观察疮疡I号外敷治疗湿热毒盛型糖尿病足部溃疡的疗效。方法:选取2016年9月—2019年9月黑龙江中医药大学附属第一医院收治的湿热毒盛型糖尿病足部溃疡患者30例，随机分为治疗组及对照组各15例。对照组给予常规治疗及局部清创，无菌油纱外敷；治疗组给予常规治疗及局部清创，疮疡I号纱条外敷，疗程均为30 d。结果:治疗后，治疗组的四项指标评分均低于对照组，中性粒细胞、超敏C反应蛋白及白细胞介素-6水平低于对照组，差异有统计学意义(P<0.05)；治疗组的白细胞介素-10水平高于对照组，差异有统计学意义(P<0.05)。结论:疮疡I号外敷治疗湿热毒盛型糖尿病足部溃疡具有较好的疗效，能够改善患者的临床症状及体征评分，降低中性粒细胞计数及超敏C反应蛋白水平，其治疗作用机制可能与组方中的有效成分对炎症因子的调节作用有关。 |
| 关键词: 糖尿病足 溃疡 脱疽 外敷 |
| DOI：10.3969/j.issn.1007-6948.2022.02.019 |
| 投稿时间：2021-05-15 |
| 基金项目: |
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| Clinical Observation on External Application of Chuang-yang I in Treating Diabetic Foot Ulcer of Damp Heat Toxin Excess Type |
| YU Tian-yi,LIANG Xue-wei,ZHAO Gang |
| Heilongjiang University of Chinese Medicine, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin (150040), China |
| Abstract: |
| Objective To observe the therapeutic effect of Chuang-yang I external application on foot ulcer of type 2 diabetes mellitus with damp heat toxin. Methods 30 patients with diabetic foot ulcer were randomly divided into treatment group and control group, 15 cases in each group. The control group was given routine treatment, local debridement and external application of sterile gauze. The treatment group was given conventional treatment, local debridement and external application of Chuang-yang I gauze for 30 days. Results Compared with the results before treatment, the results of ulcer area, pain degree, exudation volume, color score, neutrophil count and high-sensitivity C-reactive protein level proinflammatory factor level and anti-inflammatory factor level of the treatment group after treatment significantly improved, and the improvement degrees of the treatment group were better than those of the control group, which has statistical differences (P<0.05). Conclusion It is preliminarily proved that Chuang-yang I external application has good curative effect on foot ulcer of type 2 diabetes mellitus with damp heat toxin, which can improve the score of clinical symptoms and signs, reduce the neutrophil count and the level of high-sensitivity C-reactive protein. Its therapeutic effect may be related to the regulating effect of its active components on inflammatory factors. |
| Key words: Diabetic foot, ulcer, gangrene, external application |
