| 摘要: |
| 目的:探讨胃食管反流病(GERD)与胆囊切除术的相关性。并分析了影响GERD发生的因素。方法:以2018年1月1日—2019年12月31日于天津市南开医院行胆囊切除术的患者3800例为研究对象。将患者分为两组:A组胆囊切除术后GERD，B组无胆囊切除术后综合征。收集包括患者年龄、性别、血型、BMI、术前胆囊疾病类型、手术方式、反流症状评分、食管24 h pH值监测、胃镜及焦虑抑郁评分等信息。并进行单因素和多因素Logistic分析胆囊切除术后GERD发生的影响因素。结果:胆囊切除术后GERD的发生率为80.3%，反流性食管炎(RE)为33.2%。胆囊切除术后GERD与吸烟、饮酒、肥胖、刺激性饮食、碳酸饮料、焦虑、抑郁等因素显著相关。两组在性别、年龄、血型等方面无显著性差异。多因素分析证实，吸烟、饮酒、油腻饮食、辛辣饮食、BMI指数、单发胆囊结石、单发息肉、焦虑、抑郁是术后GERD的独立危险因素。结论:GERD是一个重要的并发症。胆囊切除术增加了GERD的发生率。吸烟、饮酒、油腻饮食、辛辣饮食、焦虑抑郁的肥胖患者是GERD的高危人群。 |
| 关键词: 胆囊切除术后综合征 胃食管反流病 危险因素 |
| DOI：10.3969/j.issn.1007-6948.2022.02.011 |
| 投稿时间：2021-03-19 |
| 基金项目:国家自然科学基金(81573737、82074213) |
|
| Incidence and Risk Factors of Gastroenterology Reflux Disease after Cholecystectomy |
| TANG Yan-ping,WEI Xiao-dong,KANG Li-li |
|
| Abstract: |
| Objective To investigate the correlation between gastroenterology reflux disease (GERD) and cholecystectomy. And analysis the factor that effected the incidence of GERD. Methods 3800 patients who underwent cholecystectomy during 2014 in Tianjin Nankai Hospital were enrolled in this study. The patients were divided to two groups. Group assignment: Group A gastroesophageal reflux disease after cholecystectomy, Group B without cholecystectomy syndrome. Information including age, sex, blood group, BMI, preoperative gallbladder disease type, operation mode, reflux symptom score, 24-hour esophageal pH monitoring, gastroscopy and anxiety and depression scores were collected. The univariatelogistic and multivariate analysis were conducted in the study. Results The morbidity of GERD was 80.3% and RE was 33.2% after cholecystectomy. GERD after cholecystectomy were significantly associated with the factors of smoking, drinking, obese, pungent diet, carbonated drinks, anxiety and depressed. However, there was no significant difference in sex, age and blood group between the two groups. Multivariate analysis of the variables confirmed that smoking, drinking, greasy diet, pungent diet, BMI Index, single cholecystolithiasis, single polyp, anxiety and depression were independent risk factors for postoperative gastroesophageal reflux disease. Conclusion GERD is an important complication. The cholecystectomy increased the incidence of GERD. The obese patients with smoking, drinking, greasy diet, pungent diet, anxiety and depression were at high risk of GERD. |
| Key words: Post Cholecystectomy Syndrome, GERD, risk factors |
