| 摘要: |
| 目的:研究白介素-18(IL-18)、E-钙黏蛋白(E-cadherin)和白介素-18 结合蛋白c(IL-18BPc) 在食管癌中的表达情况及与患者TNM分期、淋巴结转移和生存期的相关性。方法:选取64例食管癌患者，获取食管癌组织标本(研究组)以及正常癌旁组织标本(对照组)。应用免疫组化法检测两组标本中IL-18、E-cadherin和IL-18BPc表达情况并进行比较，分析不同临床资料患者(TNM分期、淋巴结转移、生存情况)中IL-18、E-cadherin和IL-18BPc的表达情况，分析其表达与患者临床病理特征及预后的关系。结果:研究组IL-18、E-cadherin表达阳性率低于对照组，IL-18BPc表达阳性率高于对照组，差异有统计学意义(P<0.05)。IL-18、E-cadherin和IL-18BPc在淋巴结转移(是、否)﹑TNM分期(Ⅰ~Ⅱ期、Ⅲ~Ⅳ期)﹑生存时间(≤3年、>3年)患者中的阳性率有统计学差异(P<0.05)。Spearman相关分析结果显示IL-18、E-cadherin和IL-18BPc与生存时间均具有相关性，r分别为0.638、0.578、-0.529，P值均低于0.05。Logistic回归分析显示IL-18、E-cadherin和IL-18BPc、淋巴结转移以及TNM分期均是影响患者生存情况的危险因素(P<0.05)。IL-18、E-cadherin 高表达者的5 年生存率(36.67%、35.29%)高于低表达者(11.76%、10.00%)，而IL-18BPc高表达者的5 年生存率(16.67%)低于低表达者(43.75%)，差异有统计学意义(P<0.05)。结论: IL-18、E-cadherin和IL-18BPc均在食管癌组织中异常表达，表达水平与患者病情严重程度及预后情况具有相关性，具有较好的临床应用价值。 |
| 关键词: 白介素-18 E-钙黏蛋白 白介素-18 结合蛋白c 食管癌 生存 |
| DOI：10.3969/j.issn.1007-6948.2021.05.009 |
| 投稿时间：2020-12-27 |
| 基金项目:盐城市科技计划项目(YK2016050) |
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| Expression of IL-18, E-cadherin and IL-18 Biuding Protein c in Esophageal Cancer and Correlation with TNM Stage, Lymph Node Metastasis and Survival Time |
| CHANG Li,BIAN Yong-hua,QIU Jing |
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| Abstract: |
| Objective To study the expression of IL-18 , E-cadherin and IL-18 BPc in esophageal cancer and their correlation with TNM stage, lymph node metastasis and survival time. Methods 64 cases of esophageal cancer were selected to obtain esophageal cancer tissue samples (study group) and normal esophageal squamous epithelial tissue samples (control group). The expression of IL-18, E-cadherin and IL18BPc in the two groups were detected by immunohistochemistry and compared. The expressions of IL18, E-cadherin and IL-18BPc in patients with different clinical data (TNM stage, lymph node metastasis and survival) were analyzed. The relationship between the expression and the clinicopathological characteristics and prognosis of patients was analyzed. Results The positive rates of IL-18 and E-cadherin in the study group were lower than those in the control group, and the positive rates of IL-18BPc in the study group were higher than those in the control group (P < 0.05). The positive rates of IL-18, E-cadherin and IL-18BPc in patients with lymph node metastasis (yes, no), TNM stage (I-II, III-IV), and survival time (< 3 years and > 3 years) were significantly different (P < 0.05). Spearman correlation analysis showed that IL-18, E-cadherin and IL-18BPc were correlated with survival time, r were 0.638, 0.578 and -0.529, respectively, P values were lower than 0.05. Logistic regression analysis showed that IL18, E-cadherin and IL-18BPc, lymph node metastasis and TNM stage were all risk factors for survival (P < 0.05). The 5-year survival rate of high expression of IL-18 and E-cadherin (36.67%, 35.29%) were higher than those of low expression (11.76%, 10.00%), while the 5-year survival rate of high expression of IL-18BPc (16.67%) was lower than that of low expression (43.75%), which the difference was statistically significant (P < 0.05). Conclusion IL-18, E-cadherin and IL-18BPc are all expressed abnormally in esophageal cancer, and the expression level was correlated with the severity of the disease and the prognosis of the patients, which have a good clinical application value. |
| Key words: Interleukin 18 E-cadherin interleukin-18 binding protein c esophageal cancer survival |
