| 摘要: |
| 目的:探析解毒定痛方预防骨转移瘤放疗爆发痛的临床治疗效果。方法:选取2019年8月—2020年9月河北省沧州中西医结合医院收治的恶性肿瘤骨转移患者120例，按照随机数字表法分成实验组与对照组。对照组接受常规药物治疗，实验组在此基础上服用解毒定痛方，对比两组患者治疗前、治疗1周、治疗2周、治疗3周、治疗4周、治疗后1周、治疗后2周、治疗后1月的生活质量(QOL-C30)量表评分、疼痛评分、超敏C反应蛋白(hs-CRP)和白介素-8(IL-8)水平及不良反应的情况。结果:治疗前，两组患者CRP、IL-8、疼痛评分和QOL-C30评分对比无差异(P均>0.05)；治疗1周~治疗后2周，两组患者的CRP水平呈逐步降低趋势，且组间对比差异有统计学意义(P均<0.05)；治疗2周~治疗后2周，两组患者的CRP、IL-8、疼痛评分和QOL-C30各项评分呈逐步改善趋势，且组间对比有统计学意义(P均<0.05)；治疗后1月，两组患者的CRP、IL-8、疼痛评分和QOL-C30各项评分呈逐步改善趋势，且优于治疗前、治疗1周、治疗2周、治疗3周和治疗4周，组间对比有统计学意义(P均<0.05)。实验组疼痛缓解有效率96.67%，中医症状治疗有效率为90.0%，均优于对照组的78.33%和73.33% (P均<0.05)。结论:解毒定痛方能有效减低骨转移瘤患者的CRP和IL-8的水平，改善患者放疗爆发痛的疗效，提升患者生活质量，具有一定的临床应用价值。 |
| 关键词: 解毒定痛方 骨转移瘤 放疗 爆发痛 |
| DOI：10.3969/j.issn.1007-6948.2021.04.013 |
| 投稿时间：2020-12-25 |
| 基金项目:河北省中医药管理局资助项目(2020492) |
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| Observation on the Clinical Effect of Jiedu Dingtong Decoction in Preventing Radiotherapy Burst Pain of Bone Metastases |
| MA Qin,LIU Qing-lei,WANG Miao |
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| Abstract: |
| Objective To explore the clinical therapeutic effect of Jiedu Dingtong Recipe in preventing radiotherapy burst pain of bone metastases. Methods A total of 120 patients with bone metastases from malignant tumors admitted to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province from August 2019 to September 2020 were selected and divided into experimental group and control group according to the random number table method. The control group was received conventional drug treatment, and the experimental group was taken Jiedu Dingtong Recipe on this basis. The two groups were compared before treatment, 1 week of treatment, 2 weeks of treatment, 3 weeks of treatment, 4 weeks of treatment, 1 week after treatment and 2 weeks after treatment were periods of time. The QOL-C30 score, pain score, high-sensitivity C-reactive protein (hs-CRP), interleukin-8 water (IL-8) levels and adverse reactions at the above periods of time were analyzed. Results Before treatment, there was no difference in CRP, IL-8, pain score and QOL-C30 score between the two groups of patients (Pall>0.05). From 1 week to 2 weeks after treatment, the CRP levels of the two groups showed a gradual decrease trend in the group, and the comparison between the two groups was statistically significant (Pall<0.05). From 2 weeks to 2 weeks after treatment, the CRP, IL-8, pain score and QOL-C30 scores of the two groups showed a gradual improvement trend, and the comparison between the groups was statistically significant (Pall<0.05). One month after treatment, the CRP, IL-8, pain score and QOL-C30 scores of the two groups showed a gradual improvement trend, but they were better than those before treatment. The treatment for 1 week, treatment for 2 weeks, treatment for 3 weeks, and treatment for 4 weeks were the periods of time. The comparison between groups of the above periods of time were statistically signi?cant (Pall<0.05). The effective rate of pain relief in the experimental group was 96.67%, and the effective rate of TCM symptom treatment was 90.0%, which was better than 78.33% and 73.33% in the control group (Pall<0.05). Conclusion Jiedu Dingtong Decoction can effectively reduce the levels of CRP and IL-8 in patients with bone metastases, improve the ef?cacy of radiation burst pain and improve the quality of life of patients. It has certain |
| Key words: Jiedu Dingtong prescription bone metastases radiotherapy burst pain |
