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结直肠癌患者中性粒细胞淋巴细胞比值和T淋巴细胞CD69变化的意义
韩克松,张帆,李翠玲,张静,邸泰霖,肖德亮
0
河北中石油中心医院河北廊坊 065000;河北省廊坊市人民医院河北廊坊 065000
摘要:
目的:探讨结直肠癌患者术前外周血中T淋巴细胞CD69、中性粒细胞淋巴细胞比值(NLR)变化的意义。方法:选取2016年5月—2018年12月我院收治的126例结直肠癌患者(病例组)、120例结肠息肉患者(对照组);检测两组的术前外周血中T淋巴细胞CD69、NLR,分析不同临床病理学特征的结直肠癌患者T淋巴细胞CD69、NLR表达水平的差异。结果:病例组的外周血中T淋巴细胞CD69表达低于对照组,NLR值高于对照组,差异有统计学意义(P<0.05);不同肿瘤分化程度、不同TNM分期、是否发生淋巴结转移、是否发生肿瘤淋巴血管侵犯的结直肠癌患者血中T淋巴细胞CD69表达差异有统计学意义(P<0.05);不同肿瘤分化程度、不同TNM分期、是否发生肿瘤淋巴血管侵犯的结直肠癌患者血NLR值差异有统计学意义(P<0.05)。结论:结直肠癌患者的外周血中T淋巴细胞CD69表达降低,NLR值增高,并且与肿瘤的进展有一定关系。
关键词:  结直肠癌  T淋巴细胞  CD69  中性粒细胞  淋巴细胞
DOI:10.3969/j.issn.1007-6948.2021.02.019
投稿时间:2020-07-05
基金项目:廊坊市科技支撑计划项目(2018013153)
Significance of Changes of CD69 and NLR Values in Patients with Colorectal Cancer
HAN Ke-song,ZHANG Fan,LI Cui-ling
Abstract:
Objective To explore the significance of the changes of CD69 and NLR in peripheral blood of patients with colorectal cancer before operation. Methods We selected 126 patients with colorectal cancer (case group) admitted to our hospital, and 120 patients with colon polyps treated at the same time as the control group. The NLR and the CD69 expression by T lymphocytes in the peripheral blood were detected before operation, and the differences in the expression levels of CD69 and NLR of T lymphocytes in colorectal cancer patients with different clinicopathological characteristics were analyzed. Results The CD69 expression of T lymphocytes in the peripheral blood of the case group was lower than that of the control group (P<0.05), and the NLR value of the case group was higher than that of the control group (P<0.05). The CD69 expression of T lymphocytes in the blood of colorectal cancer patients with different tumor differentiation, different TNM stages, lymph node metastasis and tumor lymphatic vascular invasion were compared, which the difference was statistically significant (P<0.05). When blood NLR values in patients with colorectal cancer were assessed in regard with different tumor differentiation levels, different TNM stages. Whether tumor lymphatic vascular invasion occurred, the difference was statistically significant (P<0.05). Conclusion The expression of CD69 on T lymphocytes in peripheral blood of patients with colorectal cancer is decreased and the value of NLR is increased. It has a certain relationship with tumor progression.
Key words:  Colorectal cancer  T lymphocytes  CD69  neutrophils  lymphocytes

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