| 摘要: |
| 目的:探讨消浊化石汤联合输尿管软镜在肾结石患者中的应用效果及对炎症因子的影响。方法:选择2018年5月—2019年7月肾结石患者94例为对象，随机数字表法分为两组，各47例。对照组采用输尿管软镜治疗，观察组在对照组基础上联合消浊化石汤治疗，14 d治疗后评估效果并完成12个月随访，比较两组中医证候积分、炎症因子、并发症及复发率。结果:观察组治疗后14 d腰腹绞痛(0.95±0.23)分、小便涩痛(1.23±0.37)分、排尿无力(1.15±0.32)分、尿中带血(0.91±0.19)分、大便干结(0.67±0.11)分及神倦乏力评分(0.84±0.25)分均低于对照组[腰腹绞痛(1.98±0.43)分、小便涩痛(2.32±0.43)分、排尿无力(2.96±0.51)分、尿中带血(2.69±0.47)分、大便干结(2.41±0.45)分及神倦乏力评分(1.68±0.16)分](t=7.132、6.339、8.571、6.983、6.484、5.983，P<0.05)；观察组治疗后14 d炎性因子IL-6水平(8.12±0.79)pg/mL及CRP水平(5.41±0.49)mg/L均低于对照组[IL-6水平(13.21±1.68)pg/mL及CRP水平(13.98±2.51)mg/L](t=4.349、5.319，P<0.05)；IL-10水平(15.93±3.41)ng/L高于对照组(11.12±2.59)ng/L(t=6.645，P<0.05)；两组治疗过程中感染、出血、失血性休克发生率无统计意义(P>0.05)；两组疗程后1、6个月复发率无统计意义(P>0.05)；观察组疗程后12个月复发率低于对照组(P<0.05)。结论:消浊化石汤联合输尿管软镜能降低肾结石患者中医症候积分，有助于降低炎症因子水平，未增加并发症发生率，能降低治疗后复发率，值得推广应用。 |
| 关键词: 消浊化石汤 输尿管软镜 肾结石 炎症因子 症候积分 |
| DOI：10.3969/j.issn.1007-6948.2021.02.017 |
| 投稿时间：2020-10-07 |
| 基金项目: |
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| Application of Xiaozhuo Huashi Decoction Combined with Flexible Ureteroscope in Patients with Kidney Stones and its Influence on Inflammatory Factors |
| WU Xiao-fang |
| Department of Urology Surgery, the First People' s Hospital of Chun' an County, Hangzhou, Zhejiang 311700, China |
| Abstract: |
| Objective To explore the application effect of Xiaozhuo Huashi Decoction combined with flexible ureteroscope in patients with kidney stones and its influence on inflammatory factors. Methods Ninety-four patients with kidney stones from May 2018 to July 2019 were selected as subjects, and they were divided into two groups by random number table, with 47 cases in each group. The control group was treated with flexible ureteroscopy, and the observation group was treated with Xiaozhuo Huashi Decoction on the basis of the control group. After 14 days of treatment, the effect was evaluated and a 12-month follow-up was completed. The scores of TCM syndromes, inflammatory factors, complications and recurrence rates were compared between the two groups. Results 14 days after treatment in the observation group, waist and abdomen colic (0.95±0.23) points, astringent urination (1.23±0.37) points, urinary weakness (1.15±0.32) points, blood in the urine (0.91±0.19) points, dry stools (0.67±0.11) points and mental fatigue score (0.84±0.25) points were lower than those of the control group [waist abdominal cramps (1.98±0.43) points, astringent urine (2.32±0.43) points, urination weakness (2.96±0.51) points, blood in the urine (2.69±0.47) points, dry stools (2.41±0.45) points and fatigue score (1.68±0.16) points] (t=7.132, 6.339, 8.571, 6.983, 6.484, 5.983, P<0.05). 14 days after treatment, the inflammatory factor IL-6 level (8.12±0.79) pg/mL and CRP level (5.41±0.49) mg/L of the observation group were lower than those of the control group [IL-6 level (13.21±1.68) pg/mL and CRP level (13.98±2.51) mg/L] (t=4.349, 5.319, P<0.05). The IL-10 level (15.93±3.41) ng/L is higher than that of the control group (11.12±2.59) ng/L (t=6.645, P<0.05). The incidence of infection, bleeding and hemorrhagic shock during the treatment of the two groups were not statistically significant (P>0.05). The recurrence rate of the two groups at 1 and 6 months after the course of treatment were not statistically signi?cant (P>0.05). The recurrence rate of the observation group was lower than that of the control group after 12 months of treatment (P<0.05). Conclusion Xiaozhuo Huashi Decoction combined with ?exible ureteroscopy can reduce the TCM syndrome scores of patients with kidney stones, help reduce the level of in?ammatory factors, without increasing the incidence of complications, which can reduce the recurrence rate after treatment. It is worthy of popularization and application. |
| Key words: Xiaozhuo huashi decoction flexible ureteroscopy kidney stones inflammatory factors syndrome score |
