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神效散外用对急性软组织损伤后肿瘤坏死因子-α、白细胞介素-1β的影响
王爱国,谷福顺,郑昆仑,陆军,赵允,王晓辉
0
天津市中医药研究院附属医院天津 300120;天津中医药大学第二附属医院天津 300250;天津市医药科学研究所天津 300020
摘要:
目的:探究神效散外用对急性软组织损伤后肿瘤坏死因子-α(TNF-α)和白细胞介素-β(IL-1β)的影响。方法:将50只大鼠随机分为5组,神效散高、中、低剂量组,空白敷贴阴性对照组,扶他林阳性对照组,建立局部软组织损伤模型,连续给药7 d后,检测血清和肌肉组织中TNF-α和IL-1β的含量。结果:第4天时,每组血清中TNF-α、IL-1β含量与阴性对照组均有统计学差异(P<0.05);第4天时,高剂量组与中剂量组肌肉组织中TNF-α、IL-1β含量与阴性对照组有统计学差异(P<0.05);第7天时中剂量组和低剂量组血清TNF-α、IL-1β含量与阴性对照组有统计学差异(P<0.05);第7天时,中剂量组肌肉组织中TNF-α、IL-1β含量与阴性对照组有统计学差异(P<0.05)。结论:中剂量组神效散外用对急性软组织局部损伤模型有较好的抗炎作用,其机制可能是使损伤组织中TNF-α、IL-1β含量降低。
关键词:  急性软组织损伤  神效散外用  局部损伤模型  肿瘤坏死因子-α  白细胞介素-1β
DOI:10.3969/j.issn.1007-6948.2021.02.006
投稿时间:2020-09-28
基金项目:天津市中医药领域重点项目(2017007);天津市中医药研究院附属医院院内科研基金(2020004)
Shenxiao San Powder for External Use on the Influence of TNF-α and IL-1β after Acute Soft Tissue Injury
WANG Ai-guo,GU Fu-shun,ZHENG Kun-lun
Abstract:
Objective To investigate Shenxiao San Powder for external use on the influence of TNF-αand IL-1β after acute soft tissue injury. Methods The rats were randomly divided into 5 groups, namely the experimental group with high, medium and low doses of Shenxiao San Powder, the control group with negative blank application and the positive control group with Votalin. The local soft tissue injury model was established and the levels of TNF-α and IL-1β in serum and muscle tissues were observed after 7 consecutive days of administration. Results On the 4th day, there were statistically significant differences in serum levels of TNF-α and IL-1β in each group compared with the negative control group (P < 0.05). On the 4th day, the levels of TNF-α and IL-1βin the muscle tissues of the high-dose group and the middle-dose group were significantly different from those of the negative control group (P < 0.05). On the 7th day, the serum levels of TNF-α and IL-1βin the medium dose group and the low dose group were significantly different from the negative control group (P < 0.05). On the 7th day, there were statistically significant differences between the levels of TNF-α and IL-1β in the muscle tissue of the medium dose group and the negative control group (P < 0.05). Conclusion The medium dose Shenxiao San Powder has a good anti-inflammatory effect on the model of acute local soft tissue injury. The mechanism may be related to the decrease of TNF-α and IL-1β in the injured tissue.
Key words:  Acute soft tissue injury  Shenxiao San powder for external use  local damage model  TNF-α  IL-1β

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