| 摘要: |
| 目的:比较双抗对照单抗血小板聚集治疗下肢动脉硬化闭塞症的临床疗效。方法:计算机检索PubMed、Embase、The Cochrane Library、CNKI、CBM、万方、维普等中英文数据库，搜集以双抗血小板聚集对照单抗血小板聚集治疗下肢动脉硬化闭塞症的临床随机对照试验。按照Cochrane 偏倚风险评价对纳入文献进行质量分析，采用Revman5.3 软件进行数据分析。结果:本次研究共纳入5 篇文献，共419 例患者，Meta 分析结果显示双抗总有效率明显优于单抗[OR ＝3.62(1.85，7.11)，I2=0%, P ＜ 0.01]，双抗治疗后踝肱指数上升优于单抗[SMD ＝ 0.44(0.22，0.67), I2=0%，P ＜ 0.01]，差异均有统计学意义。结论:双抗血小板聚集治疗下肢动脉硬化闭塞症临床总有效率及ABI 指数优于单抗。尚需更多高质量的大样本随机对照试验验证。 |
| 关键词: 下肢动脉硬化闭塞症 双抗血小板聚集药物 单抗 系统评价 Meta 分析 |
| DOI：10.3969/j.issn.1007-6948.2020.06.027 |
| 投稿时间：2019-11-25 |
| 基金项目:科技创新人才项目(2016RAQXJ209) |
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| Systematic Review and Meta-analysis of the Efficacy of Bi-antiplatelet Contrasted with Antiplatelet Monotherapy in the Treatment of Lower Extremity Arteriosclerosis Obliterans |
| Wang Ji-xue,Zhao Gang,Yu Wen-hui |
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| Abstract: |
| Objective To compare the clinical effect of double antiplatelet control mAb in the treatment of arteriosclerosis obliterans of lower extremity. Methods The Chinese and English databases of PubMed,EMBASE, the Cochrane Library, CNKI, Wanfang Data, CBM and VIP were searched by computer, and the clinical randomized controlled trials of double antiplatelet control mAb in the treatment of lower extremity arteriosclerosis obliterans were collected. According to Cochrane bias risk assessment, the quality of the literaturwas analyzed and Revman 5.3 software was used for data analysis. Results The total effective rate of double antibody was significantly better than that of the single antibody [OR=3.62(1.85, 7.11), I2=0%, P <0.01] and the ankle brachial index increased better than that of the single antibody [SMD=0.44(0.22, 0.67), I2=0%, P <0.01],which the difference was statistically significant. Conclusion Double anti-body control monoclonal antibody has obvious advantage in the total clinical effective rate of the treatment of arteriosclerosis obliterans of the lower extremities. The above conclusions need to be verified by more high-quality central large sample randomized controlled trials. |
| Key words: Arteriosclerosis obliterans of lower extremities double antiplatelet drugs antip -latelet monotherapy system evaluation meta analysis |
