| 摘要: |
| 目的:探讨小金胶囊联合左甲状腺素钠片治疗桥本氏甲状腺炎的临床研究。方法:选取2017 年8 月—2019年1 月收治的桥本氏甲状腺炎患者106 例，按照数字表法将其随机分为两组，对照组应用左甲状腺素钠片治疗，研究组应用小金胶囊联合左甲状腺素钠片治疗，对两组患者临床疗效、甲状腺功能及炎症反应等指标进行分析。结果:研究组的临床治愈比例高于对照组(50.9% vs 18.7%)；研究组的T3(2.2±0.5) nmol/L、T4(124.2±17.8) nmol/L、FT3(4.3±0.7) pmol/L 及FT4(14.4±2.9) pmol/L 与对照组无明显差异(P ＞ 0.05)，研究组的TSH(1.8±0.2) μIU/L 低于对照组(P ＜ 0.05)；研究组甲状腺抗体水平TG-Ab(253.4±12.8) IU/mL、TPO-Ab(241.3±12.8) IU/mL 均低于对照组(P ＜ 0.05)；研究组IL-8(0.4±0.2) ng/mL、IL-17(7.4±2.1) pg/mL 及APN(5.9±1.1) μg/mL 低于对照组(P ＜ 0.05)，研究组的IL-10(91.8±12.6) pg/mL 高于对照组(P ＜ 0.05)；研究组不良反应(22.64%) 与对照组(24.53%) 无明显差异(P ＞ 0.05)。结论: 采用小金胶囊联合左甲状腺素钠片治疗桥本氏甲状腺炎患者，能有效改善患者甲状腺抗体水平，调节自身炎症因子平衡，具有较高的安全性，可以在临床中进行进一步推广。 |
| 关键词: 小金胶囊 左甲状腺素钠片 桥本氏甲状腺炎 脂联素 |
| DOI：10.3969/j.issn.1007-6948.2020.03.012 |
| 投稿时间：2019-11-21 |
| 基金项目:沧州市科技支撑计划项目(162302196) |
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| Clinical Study of Xiaojin Capsule Combined with Levothyroxine Sodium Tablets in the Treatment ofHashimoto' s Thyroiditis |
| REN Yi,ZHAO Tie-zheng,WANG Yu-wen |
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| Abstract: |
| Objective To investigate the clinical study of Xiaojin capsule combined with levothyroxine sodium tablets in the treatment of hashimoto' s thyroiditis. Methods Select 106 patients with hashimoto’s thyroiditis from August 2017 to January 2019 by digital meter method. They were randomly divided into two groups. Control group was applied levothyroxine sodium treatment and study group was applied Xiaojin capsule combined levothyroxine sodium treatment. The clinical efficacy of two groups, thyroid function and inflammatory response index were analyzed. Results The curative effect of the study group (50.9%) was higher than that of the control group (18.7%) (P <0.05). There was no significant difference between T3 (2.2±0.5nmol/L), T4(124.2±17.8nmol/L), FT3 (4.3±0.7pmol/L) and FT4 (14.4±2.9pmol/L) in the study group and the control group (P >0.05). TSH (1.8±0.2μIU/L) in the study group was lower than that in the control group (P <0.05).The thyroid antibody levels of TG-Ab (253.4±12.8IU/mL) and TPO-Ab (241.3±12.8IU/mL) in the study group were lower than those in the control group (P <0.05). IL-8 (0.4±0.2ng/mL), IL-17 (7.4±2.1pg/mL)and APN (5.9±1.1ug/mL) in the study group were lower than those in the control group (P <0.05), while IL-10 (91.8±12.6pg/mL) in the study group was higher than that in the control group (P <0.05). There was no significant difference in adverse reactions between the study group (22.64%) and the control group(24.53%) (P >0.05). Conclusion The treatment of hashimoto’s thyroiditis with Xiaojin capsule combined with levothyroxine sodium tablets can effectively improve the thyroid antibody level ofpatients, regulate the balance of their own in?ammatory factors. It is highly safe and can be further promoted in the clinic. |
| Key words: Xiaojin capsule levothyroxine sodium tablets Hashimoto' s thyroiditis adiponectin |
