| 摘要: |
| 目的：探讨血清胃蛋白酶原Ⅰ（PG Ⅰ）、胃蛋白酶原Ⅱ（PG Ⅱ）、PG Ⅰ /PG Ⅱ比值（PGR）、胃泌素 -17（G-17）、幽门螺杆菌抗体（H.pylori-IgG）在不同胃黏膜疾病患者血清中的表达水平及意义。方法：选取 2016 年 1 月至 2018 年 1 月2394 名门诊及住院患者，在进行胃镜检查前，抽血检测血清 PG Ⅰ、PG Ⅱ、PG Ⅰ / PG Ⅱ、G-17 及 H.pylori-IgG。按照胃镜检查及组织病理诊断的结果分为 4 组，慢性非萎缩性胃炎 1376 例、慢性萎缩性胃炎 708 例、胃溃疡 265 例，胃癌 45 例， 统计分析不同胃黏膜病变患者胃功能四项的表达水平。结果：慢性萎缩性胃炎组 PG Ⅰ水平比慢性非萎缩性胃炎组、胃溃疡组、胃癌组低，差异有统计学意义（P<0.05）；胃癌组 PG Ⅱ、G-17 水平高于胃溃疡组、慢性萎缩性胃炎组、慢性非萎缩性胃炎组，差异有统计学意义（P<0.05）；胃癌组的 PGR 值比胃溃疡组、慢性萎缩性胃炎组、慢性非萎缩性胃炎组低，差异具有统计学意义（P<0.05）；胃癌组、慢性萎缩性胃炎组 H.pylori -IgG 的阳性率比胃溃疡组、慢性非萎缩性胃炎组组高， 差异有统计学意义（P<0.05）。结论：胃黏膜“血清学活检”指标与胃黏膜病变密切相关，可以作为胃部疾病的辅助筛查与诊断。 |
| 关键词: 胃蛋白酶原 胃泌素 17 幽门螺杆菌 |
| DOI：10.3969/j.issn.1007-6948.2019.04.010 |
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| 基金项目: |
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| Expression and Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions |
| DONG Zhi-ping,ZHAO Jiang-rong,ZHANG Xuan,ZHANG Jing-zhe |
| Department of General Surgery, Shanghai TCM-Integrated Hospital Af?liated to Shanghai University of Traditional Chinese Medicine, Shanghai（200080），China;Department of Gastroenterology, Shanghai Integrated Traditional Chinese and Western Medicine Hospital, Shanghai University of Traditional Chinese Medicine (Shanghai 200080);Surgery Department of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Shanghai 200032) |
| Abstract: |
| Objective To investigate the value of pepsinogen Ⅰ (PGⅠ)，pepsinogen Ⅱ (PG Ⅱ )， rat io of PGⅠ/ PGⅡ( PGR)， gast r i n- 17 and H. pylori-IgG in serum with different gastric mucosallesions. Methods From January 2016 to January 2018，a total of 2394 patients with digestive tract symptoms underwent gastroscopy. According to the results of endoscopic examination and pathological diagnosis, they were divided into four groups: 1376 cases of chronic non-atrophic gastritis, 708 cases of chronic atrophic gastritis, 265 cases of gastric ulcer and 45 cases of gastric cancer. Serological gastric biopsy was detected and analyzed. Results The serum levels of PG Ⅰ in chronic atrophic gastritis group was signi?cantly lower than those in chronic non atrophic gastritis group, gastric ulcer group and gastric cancer group (P<0.05)．The serum levels of PG Ⅱ and G-17 in gastric cancer group were signi?cantly higher than those in nonchronic atrophicgastritis group，chronic atrophic gastritis group and gastric ulcer group (P<0.05). PGR in gastric cancer group was signi?cantly lower than that of chronic non atrophic gastritis group, chronic atrophic gastritis group and gastric ulcer group (P < 0 . 05 ). H.pylori positive rates in chronic atrophic gastritis group and gastric cancer group were higher than those in nonchronic atrophicgastritis group and gastric ulcer group (P<0.05).Conclusion Serological gastric biopsy is closely correlated to gastric mucosal disease and can be used as an important screening tool for gastric disease. |
| Key words: Pepsinogen gastrin-17 Helicobacter pylori |
