| 摘要: |
| 目的：探讨 NK、Th17 和 Treg 细胞水平对经腹腔镜根治术后的结直肠癌患者临床结局的影响，并分析其预测结直肠癌患者的复发的价值。方法：纳入 2016 年 1 月—2017 年 1 月行腹腔镜根治术治疗的原发结直肠癌患者 120 例进行随访。采集术后第一天外周血检测 NK、Th17 和 Treg 细胞数量，采用两独立样本t 检验分析其术后复发和未复发患者间差异； 利用 logistic 回归模型判断各指标与复发的关联；最后采用 ROC 曲线分析其在预测结直肠癌术后复发的价值。结果：术后复发组 NK 和 Th17 细胞水平显著低于未复发组（P<0.05)，但 Treg 细胞水平复发组要高于未复发组（P<0.05）。经 Logistic回归分析发现，NK 细胞和 Th17 细胞是复发的保护性因素，而 Treg 细胞是独立的危险因素。ROC 曲线分析表明，NK、Th17 和 Treg 细胞水平对预测术后复发具有一定的预测价值。结论：结直肠癌患者其复发与 NK、Th17 和 Treg 细胞水平有关，是结直肠癌患者术后预后的独立影响因素，其对结直肠癌患者预后具有一定的影响，预测患者术后复发具有一定的价值。 |
| 关键词: 结直肠癌 免疫细胞 复发 影响因素 |
| DOI：10.3969/j.issn.1007-6948.2019.04.005 |
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| 基金项目:廊坊市科技支撑计划项目（2018013153） |
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| Analysis on Predictive Value of NK, Th17 and Treg Cells on Recurrence of Colorectal Carcinoma after Laparoscopic Resection |
| ZHANG Fan,DI Tai-ling,HAN Ke-song |
| Department of General Surgery, China National Petroleum Corporation Central Hospital, Langfang (065000), China |
| Abstract: |
| Objective To investigate the influences of the levels of NK cells, Th17 cells and Treg cells on clinical outcomes of patients with colorectal carcinoma after laparoscopic resection, and to analyze their predictive value for postoperative recurrence. Methods The clinical data were collected from 120 patients with colorectal carcinoma who underwent laparoscopic resection bfrom January, 2016 to January, 2017. The levels of NK cells, Th17 cells and Treg cells in peripheral blood were obtained and detected on day 1 postoperatively. Two independent t-test samples were used to analyze the difference between patients with recurrence and those without recurrence. Logistic regression model was used to determine the correlation between the indicators and recurrence. Finally, ROC curve was used to analyze its value in predicting recurrence of colorectal cancer after operation. Results We found that levels of NK cells and Th17 cells in recrudesce patients were lower than those in non-recrudesce patients (P < 0 . 05 ), but the level of Treg cells in recrudesce patients were higher than that in non-recrudesce patients (P<0.05). Logistic regression analysis found that NK cells and Th17 cells were protective factors for recurrence, while Treg cells were independent risk factors. ROC curve analysis showed that the levels of NK cells, Th17 cells and Treg cells had certain predictive value for predicting postoperative recurrence. Conclusion Levels of NK cells, Th 17 cells and Treg cells are associated with recurrence and independent prognostic influencing factors for postoperative patients with colorectal carcinoma, and its has acertain value in predicting postoperative recurrence of patients. |
| Key words: Colorectal carcinoma immune cells recurrence risk factors |
