Effect of Total Hip Arthroplasty Combined with Alendronate Tablets on Joint Function and Bone Mineral Density in Elderly Patients with Femoral Neck Fracture
GAO Xin,LI Ji-xin,GU Wen-li,YU Tong-li,BIAN Ye
Department of Orthopaedics, Pharmaceutical Preparation Section , Tianjin Beichen Hospital, Tianjin (300400), China;Department of Orthopaedics, Pharmaceutical Science , Tianjin Beichen Hospital, Tianjin (300400), China;Department of Orthopaedics, Pharmaceutical Education Section, Tianjin Beichen Hospital, Tianjin (300400), China
Abstract:
Objective To investigate the effect of total hip arthroplasty combined with alendronate tablets on joint function and bone mineral density in elderly patients with femoral neck fracture. Methods Elderly patients (100 cases) with femoral neck fracture undergoing total hip replacement were randomly divided into observation group and control group with 50 cases in each group. The patients in control group orally received Calcium D Tablets (1 tablet/time, 1 time/d) and Calcitriol Capsules (25 μg/time, 2 times/d) 7 d after total hip arthroplasty, and received routine anti-osteoporosis treatment; the observation group was treated with alendronate sodium tablets (10 mg/time, once daily) on the basis of the control group for 3 months. The hip function excellence rate and bone mineral density (BMD) after 7 d, 3 months and 6 months of operation in the two groups were observed. Results After 7 d of operation, the excellent and good rate of hip joint in observation group was 18.00% (9/50) and that in control group was 16.00% (8/50), without difference between the two groups. Three months and 6 months after operation, the excellent rate of hip joint in observation group was 74.00% (37/50), 90.00% (45/50), and was 42.00% (21/50) and 72.00% (36/50) in control group, respectively. The observation group was signi?cantly better than the control group (P<0.05). On day 7 after operation, there was no difference in bone mineral density between the two groups in seven regions of interest around the prosthesis. Three months after operation, the bone mineral density around the prosthesis in both groups decreased to some extent compared with that after 7 d of operation. The bone mineral density in ROI 1 and ROI 7 areas in the observation group was signi?cantly lower than that in the control group (P<0.05). Six months after operation, the bone mineral density of the observation group was signi?cantly higher than that of the control group except ROI 4 (P<0.05). Conclusion Total hip arthroplasty combined with alendronate tablets in the treatment of femoral neck fracture can signi?cantly improve the postoperative joint function and bone mineral density around the prosthesis. The clinical effect is obvious.
