| 摘要: |
| 目的：探讨全髋关节置换术联合阿仑磷酸钠片对老年股骨颈骨折的关节功能及骨密度水平的影响。方法：选取股骨颈骨折行全髋关节置换术老年患者 100 例，随机分成观察组和对照组各 50 例。对照组全髋关节置换术后 7 d 给予钙尔奇D 片（1 片 / 次，1 次 /d）、骨化三醇胶丸（25 μg/ 次，2 次 /d）口服，行常规抗骨质疏松治疗；观察组在对照组治疗基础上口服阿仑磷酸钠片（10 mg/ 次，1 次 /d）联合治疗，连续治疗 3 个月。观察两组术后 7 d、术后 3 个月和术后 6 个月时间点的髋关节功能优良率和假体周围7 个兴趣区（ROI 1~7）的骨密度水平。结果：术后7 d，观察组髋关节优良率为18.00%（9/50），对照组为16.00%（8/50），二组比较无差异；术后3 个月及6 个月，观察组髋关节优良率分别为74.00%（37/50）、90.00%（45/50），对照组分别为 42.00（21/50）、72.00%（36/50），观察组明显优于对照组（P<0.05）。术后 7 d，两组假体周围 7 个兴趣区的骨密度水平比较无差异；术后 3 个月，两组假体周围骨密度较术后 7 d 时均有不同程度下降，观察组 ROI 1 和 ROI 7 区骨密度下降水平明显低于对照组（P<0.05）；术后 6 个月，观察组除 ROI 4 区外，其他各兴趣区骨密度水平均明显高于对照组（P<0.05）。结论：全髋关节置换术联合阿仑磷酸钠片治疗股骨颈骨折，能明显提高患者术后关节功能和假体周围骨密度水平，临床应用效果明显。 |
| 关键词: 全髋关节置换术 阿仑磷酸钠片 关节功能 骨密度 |
| DOI：10.3969/j.issn.1007-6948.2019.02.011 |
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| 基金项目: |
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| Effect of Total Hip Arthroplasty Combined with Alendronate Tablets on Joint Function and Bone Mineral Density in Elderly Patients with Femoral Neck Fracture |
| GAO Xin,LI Ji-xin,GU Wen-li,YU Tong-li,BIAN Ye |
| Department of Orthopaedics, Pharmaceutical Preparation Section , Tianjin Beichen Hospital, Tianjin (300400), China;Department of Orthopaedics, Pharmaceutical Science , Tianjin Beichen Hospital, Tianjin (300400), China;Department of Orthopaedics, Pharmaceutical Education Section, Tianjin Beichen Hospital, Tianjin (300400), China |
| Abstract: |
| Objective To investigate the effect of total hip arthroplasty combined with alendronate tablets on joint function and bone mineral density in elderly patients with femoral neck fracture. Methods Elderly patients (100 cases) with femoral neck fracture undergoing total hip replacement were randomly divided into observation group and control group with 50 cases in each group. The patients in control group orally received Calcium D Tablets (1 tablet/time, 1 time/d) and Calcitriol Capsules (25 μg/time, 2 times/d) 7 d after total hip arthroplasty, and received routine anti-osteoporosis treatment; the observation group was treated with alendronate sodium tablets (10 mg/time, once daily) on the basis of the control group for 3 months. The hip function excellence rate and bone mineral density (BMD) after 7 d, 3 months and 6 months of operation in the two groups were observed. Results After 7 d of operation, the excellent and good rate of hip joint in observation group was 18.00% (9/50) and that in control group was 16.00% (8/50), without difference between the two groups. Three months and 6 months after operation, the excellent rate of hip joint in observation group was 74.00% (37/50), 90.00% (45/50), and was 42.00% (21/50) and 72.00% (36/50) in control group, respectively. The observation group was signi?cantly better than the control group (P<0.05). On day 7 after operation, there was no difference in bone mineral density between the two groups in seven regions of interest around the prosthesis. Three months after operation, the bone mineral density around the prosthesis in both groups decreased to some extent compared with that after 7 d of operation. The bone mineral density in ROI 1 and ROI 7 areas in the observation group was signi?cantly lower than that in the control group (P<0.05). Six months after operation, the bone mineral density of the observation group was signi?cantly higher than that of the control group except ROI 4 (P<0.05). Conclusion Total hip arthroplasty combined with alendronate tablets in the treatment of femoral neck fracture can signi?cantly improve the postoperative joint function and bone mineral density around the prosthesis. The clinical effect is obvious. |
| Key words: Replacement of total hip alendronate tablets function of joint bone density |
