A Meta-analysis on Safflower Yellow Injection Combined with Low Molecular Heparin in Prevention of Deep Venous Thrombosis after Orthopedic Surgery
LIU Yu-bo,SUN Yan,YAN Shu
Department of Clinical Pharmacy, Tianjin Nankai Hospital, Tianjin (300100), China
Abstract:
Objective To evaluate the efficacy and safety of combination of low molecular heparin (LMH) and Safflower Yellow Injection (SYI) for prevention of deep venous thrombosis (DVT) after orthopedic surgery. Methods Randomized controlled trials (RCTs) of combination of LMH and SYI for prevention of DVT after orthopedic surgery were searched from the Cochrane library, EMbase, PubMed, CNKI, VIP, and Wanfang database from January 2000 to June 2018. According to the inclusion and exclusion criteria, the data were extracted and processed by Revman5.3. Results Eight RCTs involving 624 patients were enrolled. The results showed that compared with the control group, the combined group had better effect on DVT rate [RR=0.28, 95% CI (0.16, 0.51), P<0.0001], APTT [MD=5.34, 95% CI (2.31, 8.36), P=0.0005] and PT [MD=3.09, 95% CI (1.75, 4.44), P<0.00001] levels. There was no significant difference in adverse events between the two groups. Conclusion Based on the current clinical evidence, the combination of LMH and SYI has a better effect on DVT than LMH used alone after orthopedic surgery.
