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红花黄色素联合低分子肝素预防骨科术后深静脉血栓Meta分析
刘玉波,孙岩,阎姝
0
天津市南开医院临床药学科(天津 300100)
摘要:
评价红花黄色素联合低分子肝素预防骨科术后深静脉血栓形成(DVT)的疗效及安全性。方法:全面检索PubMed、EMbase、Cochrane Library、CNKI、维普和万方数据库中收录的红花黄色素联合低分子肝素预防骨科术后DVT的随机对照研究(RCT),检索时限从2000年1月—2018年6月。提取资料进行质量评价,采用Rev Man5.3软件进行Meta分析。结果:共纳入8个RCT,包括624例患者。与对照组相比,联合组显著降低了DVT发生率[RR=0.28,95% CI(0.16,0.51),P<0.0001];联合组活化部分凝血活酶时间(APTT)[MD=5.34,95% CI(2.31,8.36), P=0.0005]、凝血酶原时间(PT)[MD=3.09,95% CI(1.75,4.44), P<0.00001]显著优于对照组。两组不良反应发生率无明显差异。结论:红花黄色素联合低分子肝素预防骨科术后DVT疗效优于单用低分子肝素。
关键词:  红花黄色素  低分子肝素  骨科手术  深静脉血栓  Meta分析
DOI:10.3969/j.issn.1007-6948.2019.01.006
基金项目:
A Meta-analysis on Safflower Yellow Injection Combined with Low Molecular Heparin in Prevention of Deep Venous Thrombosis after Orthopedic Surgery
LIU Yu-bo,SUN Yan,YAN Shu
Department of Clinical Pharmacy, Tianjin Nankai Hospital, Tianjin (300100), China
Abstract:
Objective To evaluate the efficacy and safety of combination of low molecular heparin (LMH) and Safflower Yellow Injection (SYI) for prevention of deep venous thrombosis (DVT) after orthopedic surgery. Methods Randomized controlled trials (RCTs) of combination of LMH and SYI for prevention of DVT after orthopedic surgery were searched from the Cochrane library, EMbase, PubMed, CNKI, VIP, and Wanfang database from January 2000 to June 2018. According to the inclusion and exclusion criteria, the data were extracted and processed by Revman5.3. Results Eight RCTs involving 624 patients were enrolled. The results showed that compared with the control group, the combined group had better effect on DVT rate [RR=0.28, 95% CI (0.16, 0.51), P<0.0001], APTT [MD=5.34, 95% CI (2.31, 8.36), P=0.0005] and PT [MD=3.09, 95% CI (1.75, 4.44), P<0.00001] levels. There was no significant difference in adverse events between the two groups. Conclusion Based on the current clinical evidence, the combination of LMH and SYI has a better effect on DVT than LMH used alone after orthopedic surgery.
Key words:  Safflower Yellow Injection  low molecular heparin  orthopedic surgery  deep venous thrombosis  Meta-analysis

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